7th symposium on pharmaceutical profiling in drug discovery and development
Welcome to the 7th symposium on pharmaceutical profiling in drug discovery and development
Registration for the meeting to be submitted by e-mail: firstname.lastname@example.org
before January 15, 2016
08:30 Welcome: Prof Per Artursson and Assoc Prof Christel Bergström
Session 1: Omics and Predictive Pharmacokinetics.
Chair: Prof Per Artursson, Uppsala University, Sweden
08:45 Quantitative Targeted Proteomics for ADME Predictions.
Prof Tetsuya Terasaki, Tohoku University, Japan
09:30 Quantification of ADME proteins: An inter-laboratory comparison.
Christine Wegler, Uppsala University, Sweden
09:50 Coffee break
10:30 Metabolomic and Genomic Studies Reveal New Roles for Membrane Transporters.
Honorary Doctor Lecture: Prof Kathleen Giacomini, University of California, San Francisco, USA
11:15 Challenges of disposition of therapeutic proteins – comparison to small molecules.
Dr Pawel Baranczewski, Uppsala University, Sweden
11:35 Size matters – Ussing chambers and modeling of human intestinal absorption of small molecules
Dr Patrik Lundqvist, Uppsala University, Sweden
Session 2: New technologies in drug discovery.
Chair: Dr Pawel Baranczewski, Uppsala University, Sweden
13:15 Further learnings on molecular complexity, obesity and accessibility.
Dr Michael Hann, Glaxo Smith Kline (GSK), Stevenage, UK
14:00 Microfluidics, microscopy and microbes – technologies for investigating single molecules in live
Dr Mats Walldén, Uppsala University, Sweden
14:25 Impact of intracellular unbound drug concentrations on drug effects.
André Mateus, Uppsala University, Sweden
14:45 Coffee break
Session 3: Drug delivery beyond the rule-of-5.
Chair: Assoc Prof Christel Bergström, Uppsala University, Sweden
15:30 Evolving a portfolio beyond the rule-of-5.
Dr Michael Hageman, Bristol Myers Squibb (BMS), Princeton, USA
16:15 Early prediction of drug loading in lipid-based formulations.
Linda Alskär, Uppsala University, Sweden
16:35 Molecular dynamics simulations of drug solubility in intestinal fluids and lipid-based formulations.
Dr Per Larsson, Uppsala University, Sweden
16:55 Concluding remarks.