Conference: Swedish Epigenetics and Chromatin Meeting, EpiChrom 2017


Artwork credit: Dr. Mhairi Towler – University of Dundee/Vivomotion (www.vivomotion.co.uk), Link Li and Dr. Paul Harrison – University of Dundee

The main goal of EpiChrom 2017 is to provide common grounds for meeting, networking and establishing collaboration among researchers in Sweden studying epigenetics and chromatin. Epigenetics has proven important in defining cell identity and dysregulation of epigenetic mechanisms is associated with disease.  The field studies chromatin, non-coding RNA, transcription factors and DNA modifications, among others, and their consequences on the transcriptome. Epigenetics is one of the youngest fields in Life Sciences and in recent years has witnessed an unprecedented growth. As the field is a highly interdisciplinary,  EpiChrom 2017 welcomes presentation of research spanning from molecular biology, to medicine, to bioinformatics and mathematics.

 

Registration and abstract submission is closed

Registration is closed, as the room is now full.

For questions regarding the registration, please contact elina.staaf@scilifelab.uu.se

 

Venue

Rudbecksalen, Rudbeck Laboratory, Dag Hammarskjölds väg 20, Uppsala

EpiChrom 2017 Proceedings

 

Program Day 1

08:00 Registration and coffee
08:30 Welcome address
08:40 – 10:00

Session I: Understanding Epigenetics I

8:40 Understanding the nexus between lncRNAs and chromatin-level gene expression
Chandrasekhar Kanduri, University of Gothenburg

9:20 A microarray screen identifies novel TGFbeta-regulated long non-coding RNAs
Panagiotis Papoutsoglou, Uppsala University

9:40 The Chromatin remodeling complex B-WICH is required for DNA Pol I transcription activation by glucose stimulation
Yuan Guo, Stockholm University

10:00 Coffee and sandwiches
10:30 – 11:30

Session II: Epigenetics in solid tumors

10:30 Tissue-type specific functional annotation of transcription factor motifs for prioritization of noncoding variants
Husen Umer, Uppsala University

10:50 Exosomes released by pediatric glioma stem cells induce gene expression changes in neural cells
Agota Tuzesi, University of Gothenburg

11:10 Orthotopic transplantation of pediatric glioma stem cells in mice mirrors the clinical course of the patient
Anna Wenger, University of Gothenburg

11:30 Coffee break
11:50 – 13:10

Session III: Epigenetics in hematological malignancies

11:50 A distinct gene regulatory network, established independent of coding mutations, underpins the CLL phenotype
Ayla De Paepe, Karolinska Institutet

12:10 Discovery of new molecular subgroups in pediatric ALL using DNA methylation classification and RNA-sequencing
Yanara Marincevic-Zuniga, Uppsala University

12:30 Genome-wide DNA methylation profiling in chronic lymphocytic leukemia patients carrying stereotyped B-cell receptors
Larry Mansouri, Uppsala University

12:50 Epigenetic co-regulation as a potential therapeutic target in multiple myeloma
Alba Atienza Párraga, Uppsala University

13:10 Lunch and posters
14:15 KEYNOTE LECTURE: Immune memory
Henk Stunnenberg, Radboud Institute for Molecular Life Sciences (RIMLS), Nijmegen, The Netherlands
15:15 Coffee and sweets
15:50 – 17:10

Session IV: Epigenetics and immunity

15:50 Reactivation potential of HIV-1 in primary CD4 T cells depend on the chromatin microenvironment
Peter Svensson, Karolinska Institutet

16:10 Major transcriptional changes observed in the Fulani, an ethnic group less susceptible to malaria
Jaclyn Quin, Stockholm University

16:30 Enhancer regulation by GPS2 modulates macrophage inflammation
Jaclyn Quin, Karolinska Institutet

16:50 Utilizing epigenomics to understand neurodegeneration in Multiple Sclerosis: what are the neurons telling us?
Lara Kular, Karolinska Institutet

17:10  Mingle

Program Day 2

08:30 – 10:10

Session V: Understanding Epigenetics II

8:30 Deciphering the cooperativity of Polycomb repression
Yuri Schwartz, Umeå University

9:10 Targeting Polycomb repressive complexes through evolutionary conserved DNA elements
Juan Ignacio Barrasa Lopez, Umeå University

9:40 Developmental patterning and gene regulation by the BEN-solo family
Qi Dai, Stockholm University

9:50 The future of epigenetics at SciLifeLab?
Simon Elsässer, Karolinska Institutet

10:10 Coffee and sandwiches
10:40 – 12:00

Session VI: Epigenetics across species

10:40 Ectopic application of H3K9me2 establishes postzygotic reproductive isolation in Arabidopsis
Hua Jiang, Swedish University of Agricultural Sciences

11:00 Imprinted gene regulation by the paternally expressed gene PHERES1 in Arabidopsis
Rita Batista, Swedish University of Agricultural Sciences

11:20 Genetic dissection of Drosophila HDAC3 function
Min Tang, Stockholm University

11:40 C12D8.1: A negative regulator of RNAi inheritance in Caenorhabditis elegans
Benjamin Holmgren, Uppsala University

12:00 Lunch and posters
13:00 KEYNOTE LECTURE: Computational Epigenomic Approaches for Deciphering the Non-coding Human Genome
Jason Ernst, University of California, Los Angeles (UCLA), USA
14:00 Coffee break
14:20 – 15:40

Session VII: Epigenomics

14:20 Mechanistic Insights into Autoinhibition of the Oncogenic Chromatin Remodeler ALC1
Sebastian Deindl, Uppsala University

14:40 Identification of oligodendrocyte lineage states with single-cell ATAC-seq
Eneritz Agirre, Karolinska Institutet

15:00 Protein-coding sequence exclusion by alternative transcription start site usage across the human body
Wenbo Dong, Karolinska Institutet

15:20 Nascent transcription plasticity in mouse embryonic stem cells
Rui Shao, Karolinska Institutet

15:40  Coffee and sweets
16:10 – 17:20

Session VIII: Epitools

16:10 Chromatrap®; A more efficient, sensitive & robust method of chromatin immunoprecipitation (commercial)
Lindsay Parkes

16:25 Active Motif, enables chromatin and gene regulation research (commercial)
Sarantis Chlamydas

16:40 A novel methodology for identifying genome-wide RNA-chromatin interactions
Alessandro Bonetti, Karolinska Institutet

17:00 Modelling the dynamics of epigenetic memory
Ludvig Lizana, Umeå University

17:20 Closing remarks

 

Presentations must be loaded onto the presentation computer in advance: either before the first lecture, or during the lunch or coffee breaks.

Posters are to be hung during the morning the same day as your poster session.

Company sponsors

BioNordika

Diagenode

Merck

Nordic Biolabs / Active Motif

Nordic Diagnostica / Chromatrap

 

Scientific Committee

Antonia Kalushkova*, Postdoctoral Fellow, SciLifeLab, Uppsala University (IGP)

Klev Diamanti, PhD student, SciLifeLab, Uppsala University (ICM)

Helena Jernberg-Wiklund, Professor, SciLifeLab, Uppsala University (IGP)

Jan Komorowski, Professor, SciLifeLab, Uppsala University (ICM)

 

*Contact the committee via: antonia.kalushkova@igp.uu.se