Randall S. Johnson, November 3
SciLifeLab The Svedberg seminar series
Monday, November 3
Randall S. Johnson
Dept. of Physiology, Development and Neuroscience, University of Cambridge, UK and Dept. of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden
Randy Johnson´s research focus is on mechanisms of regulation of Hypoxia Factors and the impact of hypoxia responsiveness on physiology and on pathological processes such as cancer and inflammation. He is an absolute world leading authority in the field.
The role of hypoxia and physiological response in metastatic progression
The role of the hypoxic response in angiogenesis is now understood to a significant extent at the molecular level, and involves changes in expression of the vascular endothelial growth factors, endothelin, thrombospondin, as well as a number of other growth factors and their receptors. Changes in vascular flow and modulators of vascular tension as a response to tissue hypoxia, including metabolites and small molecules like nitric oxide, are also beginning to be well understood. This presentation will concern some of my laboratories recent work trying to merge current understanding of hypoxic response, primarily through the HIF transcription factors, and vascular flow and function as it is regulated by this response; in particular, how it impinges on some of the classical and best characterized pathways of vascular structure and function in surprising ways.
Host: Lena Claesson-Welsh