Regulation of gene expression by RNA-binding proteins


Dr. Landthaler, head of the RNA Biology and Posttranscriptional Regulation research group at the Berlin Institute for Medical Systems Biology (BIMSB), will discuss posttranscriptional regulatory networks controlling gene expression in humans. 

About Dr. Landthaler
Dr. Landthaler has developed the PAR-CLIP method to profile transcriptome-wide interactions between RNA and protein. Landthaler holds a PhD from the University of Würzburg, which he gained in 2003. He worked at institutes including the Rockefeller University in New York before moving to the MDC in 2009, where he established his research group.

Abstract
The main interest of Dr. Landthaler´s group is the understanding of posttranscriptional regulatory networks controlling gene expression in humans. Nascent mRNA stably associates with a large number of mRNA-binding proteins to form ribonucleoprotein (RNP) complexes. These complexes play a key role in the regulation of spatial and temporal changes in protein synthesis by controlling transport, storage, decay and translation of mRNAs. Deregulation and failed coordination of these mechanisms contribute to pathophysiologicial development and conditions.

Photocrosslinking approaches (PAR-CLIP) and protein occupancy profiling on mRNA are used to identify regulatory RNA-protein interactions at single nucleotide resolution. In addition, we employ mRNA interactome capture in combination with mass spectrometry to characterize changes in the composition of mRNP complexes in response to changes in the immediate cellular environment.

 

This seminar is part of a seminar series hosted by SciLifeLab Fellows

 

Date: May 10

Time: 15:00-17:00

Venue: Air/Fire lecture room, SciLifeLab Solna

Host: Marc Friedländer