Robert EW Fyffe, October 27


SciLifeLab The Svedberg seminar series

Monday, October 27

 

Robert EW Fyffe

Wright State University, Dayton, Ohio, USA

Prof Robert Fyffe has contributed to understanding spinal afferent, interneuronal, and motoneuronal circuitry through detailed anatomical and physiological studies over several decades. His work currently focuses on analysis of ion channel expression in motoneurons, and the impact of peripheral nerve injury on motoneuron circuits and excitability. He also serves as vice president for research and dean of the graduate school at Wright State University.

SK channels and C-boutons on Spinal Motoneurons – Emerging Roles in Control of Excitability

C-boutons are important cholinergic modulatory loci for state-dependent and pathologic alterations in motoneuron firing rate. Muscarinic m2 receptors are concentrated postsynaptic to C-boutons, and m2 receptor activation increases motoneuron excitability by reducing the action potential afterhyperpolarization (AHP). We will illustrate that C-bouton postsynaptic sites comprise a unique structural domain containing appropriate cellular machinery for cholinergic regulation of outward potassium currents, including SK channel-mediated potassium currents that underlie the AHP. We will propose hypothetical mechanisms for the cholinergic modification of alpha motoneuron excitability at C-bouton synapses.

Host: Klas Kullander