SciLifeLab Fellows seminar series: Human eIF3-The Mediator of Translation
Speaker: Jamie Doudna Cate, Department of Molecular & Cell Biology, University of California Berkeley, USA
Regulation of protein synthesis is fundamental to all aspects of eukaryotic biology by controlling development, homeostasis, and stress responses. The 13-subunit, 800-kDa eukaryotic initiation factor 3 (eIF3) organizes initiation factor and ribosome interactions required for productive translation. We are probing eIF3 function to help explain genetic evidence connecting eIF3 deregulation with tissue-specific cancers and developmental defects. We have found that, in addition to its role in general translation initiation, eIF3 exerts control over a highly specific subset of mRNAs involved in cell growth control processes, including cell cycling, differentiation, and apoptosis. Our findings illuminate a striking parallel between the function of eIF3 in translation and the Mediator complex in transcription. I will present our structural and biochemical analyses of how eIF3 exerts its specific functions in regulating translation initiation in humans.
Jamie Doudna Cate is a Professor at UCB since 2011. He did a PhD with Jennifer Doudna in Yale, where he solved one of the first structures of ribozymes; and a postdoc with Harry Noller in Santa Cruz, revealing initial insights into the ribosomal functional complexes by X-ray crystallography. Since 2001 he is a group leader at UCB, working on the structural biology of ribosomes and biofuels. Jamie made a significant contribution to the understanding of the mRNA translation mechanism by obtaining high resolution structures of the ribosome in complex with mRNA, tRNAs and different translation factors. He also has been productively collaborating with Jennifer Doudna on CRISPR-Cas9 related structures determination. Jamie Doudna Cate is a member of American Academy of Arts and Sciences.
Date: Sept 5
Venue: Air&Fire auditorium, SciLifeLab Solna
Host: Alexey Amunts
This seminar is part of a seminar series hosted by SciLifeLab Fellows