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SciLifeLab mini-symposium: Drug Discovery and Development

How to get conclusive data from in vivo pharmacology studies? The role of ADME and pharmacokinetics.



09.30 Arrival & coffee

Session 1
Chair: Prof Per Arvidsson, SciLifeLab DDD, Karolinska Institutet, Sweden

10:00 Welcome
Prof Per Arvidsson, SciLifeLab DDD, Karolinska Institutet, Sweden

10:05 Integration of pharmacokinetics (PK) and pharmacodynamics (PD) in drug discovery
Prof Johan Gabrielsson, SLU, Sweden

11:00 Exposure in animal models – Maximizing value of ADME in vitro data
Dr Carl Pettersson, DMPK NCE Senior Designer, Merck-Soreno, Germany

11:55 Lunch

Session 2
Chair: Assoc Prof Kristian Sandberg, Uppsala University, Sweden

13:00 Using PK/PD modelling and standard ADME in vitro screens to predict therapeutic dosing in man: a case study
Dr Markus Fridén, Section Head, Modelling and Simulation, RIA iMed DMPK, Astra Zeneca

13:40 PK-PD disconnect and in vivo PD models in drug discovery
Prof Stephan Hjorth, PharmaLot Consulting AB, Sweden

14:20 Final conclusions
Assoc Prof Kristian Sandberg, Uppsala University, Sweden

14:30 Coffee break and discussion


Practical information

Venue: Trippelrummet (E10:1307-E10:1309), SciLifeLab facilities Navet, Husargatan 3, Uppsala

Registration: Please register here.

Free bus shuttle: Bus transportation from/to SciLifeLab in Solna will be arranged:

Departure from Tomtebodavägen 23A, Solna at 08.00

Departure from Husargatan 3, Uppsala at 15.30