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SciLifeLab seminar series-Campus Solna, Joseph Ecker

Monday November 11 at 15:15, Uppsala
Tuesday November 12 at 11:00, Stockholm

The seminar will be held in Uppsala  on Monday 11 November 2019, at 15:15 at BMC Uppsala
in Stockholm on Tuesday 12 November 2019, at 11:00 in Air and Fire, SciLifeLab-Campus Solna Tomtebodavägen 23a

Joseph Ecker

Genomic Analysis Laboratory, Howard Hughes Medical Institute, The Salk Institute for Biological Studies, California, U.S.A.

Ecker first became entranced by the epigenome while he was studying Arabidopsis thaliana, a small flowering plant used for basic plant biology research. In the process of the research, Ecker created a method called MethylC-Seq to map epigenetic tags in any organism. He was the first to show that the epigenome is highly dynamic in human brain cells during the transition from birth to adulthood. Now, he is charting the epigenetic differences between brain cell types to better understand disorders such as schizophrenia and Alzheimer’s disease. Ecker was also the first to map the entire human epigenome, creating a starting place for understanding the differences between different people’s epigenomes and how these variances could contribute to disease risk.

Title of the talk: Single Cell Epigenomic Analysis of the Anatomy and Neuronal Circuitry of the Brain

Our group develops and applies single cell genomic technologies to identify both the molecular signatures of individual neuronal cell types in the mammalian brain and their synaptic partners. We have developed a variety of multi-omic assays including DNA methylation, RNA-seq,  chromatin accessibility and 3D structure to study single neurons across the brain. These detailed cell atlases reveal novel cellular taxonomy in the brain and elucidate spatial diversification in fine cell subtypes. Single cell epigenomics allows identification of  cell type-specific DNA regulatory elements, providing the potential to develop new genetic tools to assess brain cell functions with greater precision.

Host: Stefania Giacomello and Björn Nystedt

Read about Joseph Ecker´s research HERE