SciLifeLab The Svedberg seminar series 2014-05-05

Stefano Gastaldello

Department of Neuroscience, Uppsala University, Uppsala, Sweden

Stefano Gastaldello obtained his PhD in 2006 by studying the function of a membrane muscle protein (alpha-sarcoglycan) and the degradation pathway of the correspondent mutated forms identified in patients affected with muscle dystrophies at the Padova University in Italy.

As a VR supported Postdoc at the Department of Cell and Molecular Biology (CMB) Karolinska Institutet he changed field to study the role of role of the Ubiquitin Proteasome System in Epstein-Barr virus infected cells and published in high impact factor journals, such as Nature Cell Biology (2010), JMCB (2012) and Plos Pathogens (2013).

He is now supported by Vetenskapsrådet young investigator grant where he will establish his independent research by combining his Postdoc knowledge on Ubiquitin/Ubiquitin-like cellular pathways with his PhD background on muscle physiology.

SUMO and Muscle

SUMOylation is an energy-dependent process catalyzed by activating, conjugating and ligating enzymes which involves the covalent but reversible attachment of the Small Ubiquitin-related Modifiers (SUMOs) to lysine residues of target proteins and thereby modulate their function, stability and localization. Post- translational modification by SUMO conjugation is emerging as an important means to regulate many cellular functions including DNA repair, genome maintenance, gene transcription and responses to endogenous and exogenous stressors like heat shock, oxidative stress, virus and bacteria infections, either at the cellular and organismic levels. Disturbance on the SUMO equilibrium has been described in many human diseases such as cerebral ischemia/stroke, cancer, skeletal muscle illnesses and heart failure.

I will present an overview how the SUMO network plays a role in the muscle physiology.

Host: Lars Larsson