SciLifeLab The Svedberg seminar series 2014-06-09
Department of Medical Psychology and Behavioral Neurobiology, University of Tübingen, Germany
Manfred Hallschmid’s primary research area is the central nervous system regulation of food intake and body weight in humans, with a particular focus on the crosstalk between nutritional and cognitive factors and the relationship between sleep and metabolism. Currently, he holds professor position in biological psychology at the University of Tübingen in Southern Germany.
The role of central nervous insulin signaling in health and disease
In recent years, the brain has emerged as a principle target of insulin effects. This assumption is supported by animal studies relying on intracerebroventricular insulin infusion and experiments in humans that make use of the intranasal pathway of insulin administration to the brain. Employing neurobehavioral and metabolic measurements as well as neuroimaging techniques, these studies have provided insight into the central and peripheral effects of brain insulin signaling. My talk will focus on effects of intranasal insulin on whole-body energy homeostasis including glucose metabolism as well as on cognition, in particular memory function. Furthermore, evidence will be reviewed that suggests a pathophysiological role of impaired brain insulin signaling in obesity and type 2 diabetes, which are hallmarked by peripheral and possibly central nervous insulin resistance, as well as in conditions such as Alzheimer´s disease where CNS insulin resistance might contribute to cognitive dysfunction.
Host: Christian Benedict