SciLifeLab The Svedberg seminar series, Erich Bornberg-Bauer
Monday March 7
Professor of Molecular Evolution and Bioinformatics, Institute for Evolution and Biodiversity, Westfalian Wilhelms University of Muenster, Muenster, Germany
Erich Bornberg-Bauer studied biochemistry and maths in Vienna where he obtained his Phd in 1995 with Peter Schuster, working on theoretical aspects of RNA and protein evolution.
Thereafter he worked as Assistant Professor in numerical mathematics before joining the German Cancer Reserach Cantre in Heidelberg (Germany), working as project manager in a startup IT company (EMl, now HITS) in Heidelberg and becoming a Senior Lecturer in Bioinformatics in Manchester (UK) in 2000.
Since 2003 he is a Full Professor of Molecular Evolution and Bioinformatics at the University of Münster (Germany) and directs a group working on bioinformatics and biophysical aspects of protein, RNA and genome evolution and collaborating with many experimental groups, mainly on genome analysis and deciphering signatures of ecological adaptation.
Domain based computational analysis of quantitative data (enables detection of de novo proteins and subtle adaptive traits)
Domains are functional, structural and evolutionary conserved units of proteins. Their de novo emergence and rearrangements of combinations can be well traced by efficient algorithms which also help drastically simplify and speed up many standard tasks in bioinformatics, such as detection and clustering of homologs, phylogeny reconstruction or analysing the completeness of genomic and RNAseq data.
We used these methods for the analysis of — so far — nine insect and two plant genomes and detected de novo emerged proteins, the expansion of domains with adaptive benefits, horizontally transmitted proteins and signals of ecological adaptation.
Read more about Erich Bornberg-Bauer’s research
Host: Mahesh Panchal