Monday May 6 at 15:15
Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva
Mirko got his PhD within the International Max Planck PhD School in Dresden, Germany in 2005 for his studies on the
link between regulated hormone secretion and gene expression in pancreatic beta cells. He did his postdoctoral work at the ETH Zurich with Markus Stoffel working on the miRNAs in obesity and insulin resistance, which led to him being appointed as a group leader and a lecturer in metabolism and metabolic diseases at the University College London (UCL) in 2012. End of 2013 he was appointed as professor at the Geneva Faculty of Medicine, and was awarded with the Swiss National Science Foundation professorship. In 2014 he won the European Research Council (ERC) starting grant, and was just recently awarded the ERC consolidator grant starting 2019. The main interests of his lab are the causes and molecular mechanisms underlying metabolic diseases, primarily obesity and insulin resistance, and in particular the roles of the adipose tissue, the gut, the immune system and the microbiota in regulation of metabolism.
Title: Gut microbiota in improving metabolic health
The intestinal microbiota is a plastic ecosystem that is shaped by environmental and genetic factors, interacting with virtually all tissues of the host. Many signals result from the interplay between the microbiota with its mammalian symbiont that can lead to altered metabolism. Disruptions in the microbial composition are associated with a number of comorbidities linked to the metabolic syndrome. In contrast, promoting the niche expansion of beneficial bacteria through diet and supplements can improve metabolic health. Reintroducing bacteria through probiotic treatment or fecal transplant, or by mimicking the mechanisms by which the microbiota signals to the host is a strategy under active investigation for multiple pathological conditions. I will discuss the recent advances in our understanding of the microbiota contribution to host physiology, the modulation of the microbiota by dietary habits and life style interventions, and the potential therapeutic benefits of reshaping the gut bacterial landscape in context of metabolic disorders such as obesity.
Host: Radiosa Gallini