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SciLifeLab The Svedberg seminar series, Gerhard Schuetz, Quantifying in quantitative cell biology

Monday 1 April
Tuesday 2 April

The seminar will be held in Uppsala  on Monday 1 April 2019, at 15:15 at BMC Uppsala
in Stockholm on Tuesday 2 April 2019, at 15:00 at Auditorium Air and Fire, SciLifeLab Campus Solna

Gerhard Schütz

Technical University Vienna, Biophysics Group, Institute of Applied Physics, Vienna, Austria

Prof. Gerhard Schütz studied physics at the Johannes Kepler University Linz, where he received his PhD (1997) and his habilitation (2004). From 2004 – 2011 he was Associate Professor at the Johannes Kepler University Linz. In 2011, he was appointed full professor at TU Wien. Gerhard Schütz has been working in the field of single molecule biophysics since the beginning, and recently included also superresolution microscopy in his portfolio.

Quantifying in quantitative cell biology: how, what, and why?

Quantification is the heart of every scientific discipline, as it provides a solid basis to mathematical models, which are required for understanding complicated systems. Since a few ten years, researchers have started to model also cell biological processes mathematically, yielding predictions that are testable by experiments. In many cases, however, the outcome was rather disappointing: many models did not assume the correct molecular mechanism, thereby leading to increased confusion instead of clarifications. Part of the problem are limitations in current measurement technologies; ideally, we would like to directly observe and quantify molecular processes in the natural cellular context. In my talk I will showcase by a few examples, how we can determine molecular parameters like protein association, its kinetics, and its dependence on the cellular environment directly in the living cell using single molecule techniques. I will highlight parameters that have been largely overlooked, such as forces acting on biomolecules. Finally, I will also show some pitfalls that may occur on our way to quantitative results.

Host: Stefan Wennmalm