The battle front in your gut – bacterial attack and host cell defense in the intestinal mucosa


Speaker: Mikael Sellin, Associate Senior Lecturer at Uppsala University and SciLifeLab Fellow

Abstract

The intestinal epithelium constitutes a single-layered barrier that separates the microbe-rich gut lumen from the body´s sterile tissues. However, pathogenic bacteria, such as Salmonella Typhimurium, can invade into and breach this barrier. Here, I will talk about bacterial attack, host tissue defense, and an act of cellular self-sacrifice in the protection against enterobacterial gut disease.

Short Bio

Mikael Erik Sellin, born in Örnsköldsvik in northern Sweden, did his MSc thesis work in a stem cell laboratory at the Karolinska Institute, Stockholm. He went on to pursue PhD studies at Umeå University within the field of mammalian cell biology and cytoskeleton regulation. After his dissertation he decided to switch research focus and has since then spent ~5 years at the ETH Zürich, Institute of Microbiology, investigating the mechanisms of pathogenesis during Salmonella Typhimurium gut infection. In the end of 2016 he was appointed SciLifeLab Fellow and Associate Senior Lecturer at Uppsala University and is currently building up a laboratory at the Department of Medical Biochemistry and Microbiology. The Sellin laboratory employs organotypic tissue culture and studies of intact gut tissue to unravel enteropathogen – host cell interplay under physiological infection conditions.


Date: 
Jan 18

Time: 15:00-15:40

Venue: Gamma 2 lunch room, SciLifeLab Solna

Please contact Mikaela Friedman, mikaela.friedman[at]scilifelab.se if you have any questions.