SciLifeLab The Svedberg seminar series, Dario Neri, Combinatorial Libraries
Monday September 11
Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology (ETH Zürich) Switzerland
Dario Neri studied Chemistry at the Scuola Normale Superiore of Pisa and earned a PhD in Chemistry at the Swiss Federal Institute of Technology (ETH Zürich), under the supervision of Professor Kurt Wüthrich. He then performed post-doctoral research at the Medical Research Council Centre in Cambridge (UK), under the supervision of Sir Gregory Winter. He has now been a Professor at the ETH Zürich since 1996.
From encoded combinatorial libraries to targeted therapeutics
Advances in technologies for the construction and screening of large combinatorial libraries of proteins (e.g., antibody phage display libraries) or of small organic ligands (e.g., DNA-encoded chemical libraries) have facilitated the isolation of specific binders against protein targets of pharmaceutical interest.
In this lecture, I will show examples of how my lab (in collaboration with Philogen; www.philogen.com) has used antibodies or small organic ligands, isolated from large combinatorial libraries, for the design of new pharmaceutical agents, capable of selective localization at the site of disease.
In particular, I will present how (i) antibody-cytokine fusion proteins can be potently active in preclinical models of disease and in clinical trials, and how (ii) small molecule-drug conjugates outperform antibody-drug conjugates for cancer therapy applications
Host: Kristian Sandberg (email@example.com)