News - 2013
SciLifeLab chosen for large EU-project to improve Baltic Sea health
In November, the first seven projects in the EU research program BONUS for viable ecosystems in the Baltic Sea were selected. One of them is BLUEPRINT, which aims at developing a genetic tool for environmental monitoring of the sea. All the DNA sequencing performed in the project will be carried out at SciLifeLab.
Variety of genetic risk factors behind bone cancer in dogs
Bone cancer in dogs is affected by a variety of genetic risk factors. SciLifeLab researchers from Uppsala University show this in a new study published in Genome Biology.
Juggling research projects
To coordinate research is more or less equivalent to creating order within chaos. Cecilia Johansson makes sure that things goes smoothly within the research group and the Domestic Animals facility.
Winners of Science & SciLifeLab Prize visited SciLifeLab in Stockholm
Following the award ceremony at Grand Hotel on December 9th , the winner of Science and SciLifeLab Prize and the three runner-ups came to SciLifeLab in Stockholm for an open seminar and a tour of the facility.
The Science & SciLifeLab Prize winner lecture
By using bats as a model system Daniel G. Streicker shows how infectious diseases can be transmitted between species.
The Human Protein Atlas reaches a major milestone
The Human Protein Atlas has reached a major milestone by releasing protein data for more than 80% of the human protein-coding genes and RNA expression data for more than 90% of the genes. The normal tissue atlas now provide a distribution map of both protein and gene expression.
Action in the Hub
Akademiska Hus are finished with the building of the Hub (Navet) in Uppsala and have handed over the keys to the Buildings Division at Uppsala University who are now in progress of putting all of the furniture in place. The first ones to move in to the new building will do so next week and […]
Winners of Science & SciLifeLab Prize announced
Bats Illuminate Ways to Control and Prevent Disease – Research Earns International Prize for Young Scientists. For his novel research using viral infections in bats to help answer questions about how infectious diseases jump between species, Daniel G. Streicker has been named the 2013 Grand Prize winner of the Science & SciLifeLab Prize for Young Scientists.
VINNOVA funds two SciLife Innovation projects
Under the auspices of SciLife Innovation, two research projects between companies and SciLifeLab scientists recently received funding from VINNOVA.
Detailed cancer diagnostics with new analysis method
New cancer treatments require good prior characterization of the tumour. Today, molecular diagnostics is time-consuming work, and important knowledge is still lacking when it comes to how drugs should best be used for individual patients. Scientists at the Science for Life Laboratory in Uppsala and Stockholm have now developed a new technique for discovering mutations in cancer tissues. The study is now published in Oncotarget.
New technology to combat blood poisoning
Researchers at SciLifeLab were recently granted money from Uppsala BIO-X to develop a new lab-on-a-chip diagnostic tool for early and rapid diagnosis of sepsis. The hope is that the technology will not only save lives but also reduce the development of antibiotic resistance by offering prescription only to patients who would benefit from the treatment.
Important clue to how the circulatory system is wired
A new mechanism that regulates the way blood vessels grow and connect to each other has been discovered by an international team of researchers at Karolinska Institutet in Sweden, and Heinrich Heine University Düsseldorf, Germany. The knowledge might open up new opportunities for future cancer therapy. The study is published in the scientific journal Proceedings of the National Academy of Sciences, PNAS.
Ancient Siberian genome reveals genetic origins of Native Americans
In collaboration with an international team of scientists, SciLifeLab assiociated scientists reports a breakthrough in the quest for Native American origins in this week’s Nature (Advance Online Publication). The genome sequence of a 24,000-year-old Siberian individual has provided a key piece of the puzzle by demonstrating genomic signatures that are basal to present-day western […]
Protein coding “junk genes” may be linked to cancer
By using a new analysis method, researchers at Karolinska Institutet and SciLifeLab in Sweden have found close to one hundred novel human gene regions that code for proteins. A number of these regions are so-called pseudogenes, which may be linked to cancer. The expectation is now that this recently developed protein analysis method, published in the scientific journal Nature Methods, will open up a whole new field of research.
SciLifeLab upgrades four additional platforms to national status
SciLifeLab has previously offered national service within the five areas Bioinformatics, Chemical biology, Drug Discovery and Development, Genomics, and Structural Biology. On October 29, SciLifeLab increased the offer of services, technologies and competence on a national basis to include the areas Affinity Proteomics, Bioimaging, Clinical Diagnostics and Functional Genomics, adding up to nine national platforms in total.
Release 3.0 of the FunCoup database of functional coupling networks
A new version of the FunCoup database has been released. FunCoup is a database of functional couplings, or functional associations, between genes and gene products. Identifying these functional couplings is an important step in the understanding of higher level mechanisms performed by complex cellular processes. FunCoup 3.0 contains networks for human and 10 model organisms. The human network consists of over 18,000 genes and proteins connected to each other with over 4 million links.
Predicting the behavior of leukemic cells
Jessica Nordlund just met with her fellow committee members to decide which well renowned researchers should be invited to Uppsala this spring. Jessica Nordlund spends most of her working hours in front of her computer, analyzing genomics data. The research project that she is part of is focused on genetics and epigenetics of pediatric […]
Ulf Landegren awarded for his entrepreneurship
‘Hjärnäpplet’, Uppsala University’s award for successful knowledge transfer, is being given to Professor Ulf Landegren for his entrepreneurial work in the field of molecular analyses in medicine and biology.
Stimulating interaction with Nobel Laureates in Chemistry
Nobel Laureates in Chemistry Michael Levitt and Arieh Warshel have long collaborated with researchers at Stockholm University. The computer models that the winners have developed are of great importance for research in membrane proteins at Stockholm University and SciLifeLab.
Shar-Pei dogs’ genetics tell us about inflammation
An international collaboration has revealed that one common genetic risk factor predisposes the Shar-Pei dog breed not only to recurrent fever, but also to a spectrum of persistent inflammatory signs that affect the skin, joints, ears and body as a whole. The study is published today in the open access journal PLOS One. Read the […]
Bringing academic discoveries closer to patients
SciLifeLab is now launching a new Drug Discovery and Development platform. This national resource will offer drug discovery expertise to Swedish researchers in order to advance academic discoveries towards novel treatments of benefit to patients.
Crown Princess Victoria visits Uppsala
Crown Princess Victoria visited Uppsala on October 11th to learn more about research and development in life sciences and energy research. She met with a number of representatives from SciLifeLab in Uppsala as well as County Governor Peter Egardt.
Crucial new insight into sodium-potassium pumps
The sodium-potassium pump is a vital enzyme found in all human cells that maintains an exact balance of sodium and potassium ions on either side of the cell membrane. The pump is required for several vital processes, such as the transport of nutrients into the cell, and any malfunction is closely linked to disease. A malfunctioning pump in brain cells results in severe neurological conditions such as migraine with aura, muscle spasms or one-sided paralysis (hemiplegia).
Several susceptibility genes for Sjögren’s syndrome identified
Discovery and refinement of loci associated with lipid levels
Using genome-wide and custom genotyping arrays, a SciLifeLab-associated research group has found that loci associated with blood lipid levels are often associated with cardiovascular and metabolic traits, including coronary artery disease, type 2 diabetes, blood pressure, waist-hip ratio and body mass index. The results demonstrate the value of using genetic data from individuals of diverse […]
A rather special prize will be awarded in Stockholm, Sweden, this December
The journal Science and SciLifeLab have come together to recognize excellence amongst young researchers. The Science and SciLifeLab Prize is a global prize established to celebrate and support young scientists at the start of their career.
Solving the puzzle of mankind
Mattias Jakobsson was drawn to genetics because of its connection to mathematics. This October he will be speaking at the symposium Human Evolution in Uppsala. What is it that makes us human and what genetic changes have been crucial for human evolution? These are some of the questions that Mattias Jakobsson addresses in his […]
New insight on degradation of short peptides in the cell
New insight on the degradation of short peptides in the cell is presented in the journal PNAS. The results may be of importance for research on Alzheimer’s disease and other age-related diseases. The article is a result of a collaboration project between researchers at Stockholm University, researchers at SciLifeLab, Karolinska Institutet and researchers at La Trobe Univerity, Australia.
Apply for bioinformatics support in next-generation sequencing projects
The third round of applications for long-term bioinformatics support at the Wallenberg advanced bioinformatics infrastructure (WABI) is now open. Researchers from Swedish universities are welcome to apply for bioinformatics support in any type of next generation sequencing projects.
NGI on roadshow
SciLifeLab’s Genomics platform, The National Genomics Infrastructure (NGI), is on a roadshow to Linköping University, Lund University and Umeå University during September 10th – 17th. The road trip aims to spread knowledge about the infrastructure and the services it provides. The representatives from NGI also look forward to meeting researchers interested in using massively parallel […]
On the lookout for genetic mutations
Lars Feuk is making himself at home at BMC and preparing for the dissertation of his first PhD student. Lars Feuk says that the best thing about his research is that it is challenging and competitive. − I believe that you need to be a competitive type of person to be a researcher. You […]
SciLifeLab-DAY attracted a large audience
The lecture hall was filled to the brim on Monday August 26th, when Uppsala and Stockholm arranged the first joint SciLifeLab-DAY. The event offered a mix of presentations and interactive meetings. Over 300 people gathered at BMC, Uppsala, on the first Uppsala and Stockholm co-arranged SciLifeLab-DAY. – Uppsala and Stockholm has enjoyed a close […]
Research projects at SciLifeLab recieves long-term support from AstraZeneca
Today AstraZeneca announced the decision to fund ten research projects at the Science for Life Laboratory. Three of these are led from Uppsala University and the remaining ones from Karolinska Institutet.
New method reads the genetic code directly in tumour tissue
Accurate diagnostic tests are crucial when choosing the right treatment regime for cancer patients. This is why scientists from Stockholm University and Uppsala University continuously work on improving methods for analysing cancer tissues. For the first time, it is now possible to read the genetic code of individual cancer cells in their original location in the tissue. The results are published in Nature Methods.
The national SciLifeLab starts today
NEWS, 1 July 2013] SciLifeLab has become a national centre with a new organisation as of today. The joint management from Stockholm and Uppsala is in place to lead the next phase of SciLifeLab and the first four national platforms have been approved.
The Science&SciLifeLab Prize for Young Scientists
SciLifeLab have joined forces with the journal Science to bring a new global prize to young scientists at the start of their career. The Science & SciLifeLab Prize for Young Scientists has been created to recognize excellence in PhD research.
Unique resource of proteins for profiling autoimmune diseases
[NEWS, 4 June 2013] Protein microarrays, representing more than one third of all human proteins, provide a unique possibility to study complex autoimmune diseases, such as multiple sclerosis (MS). In a study, published in Molecular & Cellular Proteomics, scientists from KTH Royal Institute of Technology at SciLifeLab have identified a set of novel proteins that could differentiate groups of MS patients based on the severity of disease and how the disease is developed over time.
The Norway spruce genome sequenced
Swedish scientists have mapped the gene sequence of Norway spruce (the Christmas tree) – a species with huge economic and ecological importance – and that is the largest genome to have ever been mapped. The genome is complex and seven times larger than that of humans. The results have been published in the prestigious journal Nature.
IGP in place at BMC
Friday, May 17 offered both exhibitions and canapés as the Department of Immunology, Genetics and Pathology (IGP) celebrated that the first research groups are now in place at BMC. At the end of the year the SciLifeLab move will be completed.
SciLifeLab takes on the challenge as a national resource
The Science for Life Laboratory (SciLifeLab) board held their first meeting today to discuss the direction and principles for SciLifeLab as a national resource of advanced technology and expertise in molecular biosciences. Several key positions were appointed during the meeting.
Researchers identifies gene associated with eczema in dogs
A novel gene associated with canine atopic dermatitis has been identified by a team of researchers led by professors Kerstin Lindblad-Toh, Uppsala university and Åke Hedhammar, SLU, Sweden. The gene encodes a protein called plakophilin 2, which is crucial for the formation and proper functioning of the skin structure, suggesting an aberrant skin barrier as a potential risk factor for atopic dermatitis.
Pushing down the price on expensive technology
For more information in swedish: Pushing down the price on expensive technology
New insight into the evolution of terrestrial vertebrates
New research results published in the scientific journal Nature this week shows that the lungfish, not the coelacanth, is most closely related to the organism that first walked onto land. Kerstin Lindblad-Toh, professor in comparative genomics and director at SciLifeLab in Uppsala, has led the studies where an international consortium of researchers mapped the coelacanth genome and compared it with the DNA of terrestrial vertebrates.
Thomas Helleday and Kerstin Lindblad-Toh receive 2013 Göran Gustafsson award
SciLifeLab researchers Thomas Helleday and Kerstin Lindblad-Toh receive the Göran Gustafsson award. The prize is Sweden´s largest national research prize in natural science to young researchers.
Low-cost diagnostics close to patient with novel Lab-on-DVD system
Standard DVD drives can now be used as a laser scanning microscope for low-cost diagnostics of biomolecules. Scientists from the Royal Institute of Technology (KTH) shows in a recent publication in the journal Lab on a Chip that existing optics in DVD drives can with some modifications be used as an inexpensive alternative for diagnostics in the field.
Polymer foils for low cost diagnostics
Scientists at the Royal Institute of Technology (KTH)/SciLifeLab and Fraunhofer EMFT in Germany show how flexible polymer foils are used to integrate electronics, microfluidics and DNA microarray technology for single mutation DNA analysis.
Securing regrowth in the scientific community
Tomorrow’s research starts today. SciLifeLab seized the opportunity to make children and young adults interested in life science during SciFest 2013.
New method reveals proteins by colour coding
Knowledge about how proteins interact with each other is essential for understanding cellular function. With a new method, developed at IGP, researchers can simultaneously study several different proteins in individual cells. The method might contribute to the development of improved diagnostics and new drugs.
Version 11.0 release of the Human Protein Atlas
Today the latest version of the Human Protein Atlas was released. A mile-stone has been achieved with data for 75% of the human protein-coding genes and protein evidence for all human genes predicted from the genome sequence.
Enzyme kinetics and inhibition– more information in a smaller format
A new prototype for fast and cheap measurements of enzyme characteristics has been developed by scientists at SciLifeLab. According to a new study, published in Lab on a Chip, enzyme properties in various conditions can now be studied in multiple parallel reactions using droplet microfluidic technology. This will allow large screenings of enzymes important for pharmaceutical and bioenergy development.
Combination of imaging-based methods reveals the localization of hundreds of proteins in the cell
In the first large systematic study of protein localization in the cell, 263 previously unlocalized proteins could be mapped to individual compartments in the cell and the existence of 65 proteins was shown for the very first time. In total, more than 500 proteins were analyzed with two well-established methods used in most laboratories for biological studies; immunofluorescence (IF) and fluorescence protein (FP) tagging.
Mattias Jakobsson has received Tage Erlander’s prize for natural science and technology (biology)
Read more (in Swedish)
AstraZeneca / SciLifeLab – Joint Research Collaboration Invitation for Project Pre-Proposals
n April 2012 AstraZeneca joined Knut and Alice Wallenberg foundation and the Swedish Government in a combined effort to support work at SciLifeLab. AstraZeneca is committed to supporting integrated relevant projects with the scientific community at the Universities responsible for SciLifeLab for a period of up to 5 years. During the first half of 2013, AstraZeneca will therefore identify and initiate approximately 5-10 open collaborative research projects, based on new or existing strong interdisciplinary networks. The focus is translational science and patient related research focusing on disease understanding, target validation and finding/validating new therapeutic opportunities. Areas of interest include neuroscience, cancer, respiration, inflammation, diabetes/metabolism, cardiovascular disease and infection.
Ability to digest human foods important in domestication of dogs
Press release from Uppsala University: Scientists at SciLifeLab Uppsala and the Broad Institute show, in a study published in Nature today, that the genome of dogs and wolves differ in some important ways. There are crucial differences in genes underlying brain development and function, but also an adaptation of the digestive system to more resemble that of humans.
The Human Protein Atlas becomes pilot project in building the largest European research infrastructure for biological information
The Human Protein Atlas is one of five pilot projects selected for the construction phase of the European research infrastructure for biological information (ELIXIR). SciLifeLab hosting parts the Human Protein Atlas program will be collaborating with the ELIXIR coordinator EMBL-EBI in exploring possibilities to link the data held in the Human Protein Atlas with other data resources.
Learning the alphabet of gene control
Scientists at Karolinska Institutet in Sweden have made a large step towards the understanding of how human genes are regulated. In a new study, published in the journal Cell, they identified the DNA sequences that bind to over four hundred proteins that control expression of genes. This knowledge is required to understand how differences in genomes of individuals affect their risk to develop disease.
International study suggests human genes influence gut microbial composition
New research led by the Karolinska Institutet, Sweden and the University of Glasgow, Scotland, has identified a link between a human gene and the composition of human gastrointestinal bacteria. In a study published as a letter to the journal Gut, the team outline new evidence suggesting that the human genome may play a role in determining the makeup of the billions of microbes in the human gastrointestinal tract collectively known as the gut microbiota.