News - 2018


2018-12-10, NEWS

Drugs defusing ALS-causing peptides identified

In a novel study published in Cell Chemical Biology, a group of researchers led by Oscar Fernandez-Capetillo (Karolinska Institutet/SciLifeLab) have identified drugs that limit the toxicity of arginine-rich peptides known to cause the neurodegenerative disease amytrophic lateral sclerosis (ALS). The analyses were enabled by the SciLifeLab Cell Profiling facility. At present, there is no cure […]

2018-12-06, NEWS

Nobel Laureate Gregory P. Winter visits SciLifeLab

Today, on December 6, SciLifeLab welcomed Nobel Laureate Sir Gregory P. Winter to its Stockholm site. Professor Winter is a biochemist of the University of Cambridge, UK, and awarded this year’s Nobel Prize for his work on phage-display for antibodies.

Phage display is a laboratory technique where a bacteriophage, a virus that infects bacteria, is used to develop new proteins. Gregory Winter has used phage display for the directed evolution of antibodies, with the aim of producing new pharmaceuticals.

2018-12-06, NEWS

SciLifeLab postdoc wins Skolar Award

On December 5, SciLifeLab postdoc Sandra Jernström (Karolinska Institutet) won the Skolar Award research pitching competition in Helsinki, Finland. Her project aims to find a new kind of treatment to cancer by analyzing not just the type of cancer but also the tumor composition. For winning, Sandra Jernström receives a research grant of 100 000 Euros. She is currently a postdoc in the research group of Olli Kallioniemi (Karolinska Institutet/SciLifeLab).

“I have never won such a big prize, so I am baffled how to react. The other pitches were so good. I am extremely happy now”, Sandra Jernström says.

2018-12-06, NEWS

Bacteria reduce acidic mining wastewaters

A study from researchers at Linnaeus University in Kalmar has characterized bacteria active in bioengineered environments set-up to decontaminate waste from the industrial process extracting metals from sulfide ores.The study was enabled by sequencing at the SciLifeLab National Genomics Infrastructure (NGI). When wastes from such sulfide mineral processing are exposed to water and oxygen they […]

2018-12-06, NEWS

Frizzleds receptors possible targets for treating major common diseases

A recent paper in Science Signaling highlights a family of receptors known as Frizzleds as potential drug targets in treatment of cancer, fibrosis and cardiovascular diseases. The study is led by Gunnar Schulte (Karolinska Institutet) and researchers from Germany, and conducted in collaboration with SciLifeLab Fellow Jens Carlsson (Uppsala University/SciLifeLab). The team identifies how these Frizzleds […]

2018-12-05, NEWS

Parkinson’s disease research collaboration awarded by Chan Zuckerberg Initiative

Today, the Chan Zuckerberg Initiative (CZI), co-founded by Facebook CEO Mark Zuckerberg, announced over 51 million USD in funding to launch the its Neurodegeneration Challenge Network. One of the nine collaborative science teams awarded is Profiling and Defining Parkinson’s Disease, involving SciLifeLab contributors. This awarded Swedish partnership around Parkinson’s disease is set up to systematically […]

2018-12-05, NEWS

SciLifeLab researchers awarded this year’s Rudbeck and Linnaeus Medals

The winners of this year’s Linnaeus and Rudbeck Medals, awarded by Uppsala University for extraordinarily outstanding research, have now been announced. The Linnaeus Medal is awarded to SciLifeLab researcher Leif Andersson, and one of the Rudbeck Medals to Per Artursson, also a SciLifeLab researcher.

2018-12-04, NEWS

Expertise and technologies mobilized around seven research themes

To facilitate internationally competitive, cutting-edge collaborative research, SciLifeLab supports seven Research Community Programs – networks that connect top researchers across Sweden with each other and with the SciLifeLab infrastructure.

2018-11-30, NEWS

Blood-brain barrier unlikely culprit behind nervous system pathologies in diabetes

Results from a recent study on mice challenge the previous notion of what is causing the cognitive impairment and central nervous system pathologies associated with diabetes. The investigation, lead by Guillem Genové from Karolinska Institutet, shows that no blood-brain barrier dysfunction can be observed in diabetic mice. RNA sequencing analyses were enabled by the SciLifeLab […]

2018-11-28, NEWS

Three subtypes of common liver cancer identified

A study led by Adil Mardinoglu (KTH/SciLifeLab) uncovers three distinct tumor subtypes of hepatocellular carcinoma. Due to tumor heterogeneity, effective treatment methods for this form of liver cancer, which is one of the most frequent ones, are limited. By integrating genomics and proteomics data with a metabolic network-driven analysis, the researchers could successfully characterize three […]

2018-11-26, NEWS

New Exposome Research at SciLifeLab

The Ultratrace NonTarget Lab (UnTarget Lab) at SciLifeLab. Image credit: Jonathan Martin.  The exposome is a relatively new concept in life sciences, broadly defined as our lifelong exposure to environmental factors. Measuring the exposome is a complement to the genome, and is important because genetics alone cannot explain the vast majority of chronic disease. Nontarget […]

2018-11-23, NEWS

Winners of the Science & SciLifeLab Prize for Young Scientists 2018

The winners of Science & SciLifeLab Prize for Young Scientists are now announced! The four researchers, all performing outstanding research early in their careers, will visit Sweden in December to receive their award, meet some of the leaders in their fields and present their work at the scientific symposium on December 12. Until then, make sure to hear their stories and catch up on their prize winning work!

2018-11-22, PRESS

Pressmeddelande: Upptäckt koppling mellan tarmfloran och fetma belönas när pris för unga forskare delas ut i Stockholm

Fyra unga forskare välkomnas inom kort till Sverige för att ta emot den internationella utmärkelsen Science & SciLifeLab Prize for Young Scientists, som delas ut för sjätte gången. Förstapristagaren Christoph Thaiss från University of Pennsylvania i USA belönas för att ha funnit att molekyler som produceras av tarmbakterier kan förändras under tre förhållanden som kunnat kopplas […]

2018-11-21, NEWS

National commitment to precision medicine through Genomic Medicine Sweden

Sweden is deepening its commitment to precision medicine, both within health care and clinical research. Genomic Medicine Sweden, an initiative with origins at SciLifeLab, has now received over 80 MSEK in funding, in order to enable the utility of clinical genomics in health care nationwide.

2018-11-20, NEWS

Inflammation inhibitor discovered

What if you could block the release of inflammatory proteins and thereby cure or relieve diseases such as severe asthma and sepsis? A multidisciplinary team of researchers, co-led by SciLifeLab researcher Thomas Helleday, may be on the path to just that. The researchers have developed an anti-inflammatory drug molecule with a new mechanism of action. By inhibiting a certain protein, they have been able to reduce the signals that trigger an inflammation.

2018-11-14, NEWS

The constraints of cyanobacterial growth

How is cyanobacterial growth constrained by abundance of light and CO2? A new study, led by SciLifeLab researcher Paul Hudson (KTH), delves deeper into the question. Using shotgun proteomics in the lab of Mathias Uhlén (KTH), also a SciLifeLab researcher, the group were able to examine the cyanobacteria proteome and how it reacted to variations […]

2018-11-13, NEWS

Oligodendrocytes suggested key players in development of multiple sclerosis

A recent study led by Gonçalo Castelo-Branco at Karolinska Institutet shows that oligodendrocytes, a cell type in the brain and spinal cord, might have a significant role in the development of multiple sclerosis (MS). The project was enabled by the National Genomics Infrastructure (NGI), the Eukaryotic Single Cell Genomics Facility (ESCG) and the National Bioinformatics platform (NBIS) […]

2018-11-13, NEWS

How pneumococci evade the immune system

A novel study led by Birgitta Henriques-Normark at Karolinska Institutet sheds light upon how pneumococci inhibit immune reactions and survive inside human cells, causing pneumonia. Parts of the analyses were enabled by the Mass Spectrometry Based Proteomics facility of SciLifeLab. Pneumococci bacteria are found in the normal flora of healthy individuals of all ages, including […]

2018-11-08, NEWS

Japanese Business federation KEIDANREN visits SciLifeLab

The Japanese Business federation KEIDANREN, along with the newly appointed Japanese ambassador to Sweden, H.E. Shigeyuki Hiroki, visited SciLifeLab on Wednesday Nov 7 as part of KEIDANREN’s Mission to Sweden 2018. The mission is part of the ongoing 150th anniversary of diplomatic relations between Japan and Sweden. In addition to SciLifeLab, the delegation visited Ericsson, the Confederation […]

2018-11-05, NEWS

Online gamers and artificial intelligence to improve image classification

As reported back in 2016, Emma Lundberg’s research group has, by collaborating with the gaming company Massive Multiplayer Online Science, had their project about classification of protein images included in the online game EVE. EVE is played by over half a million people every month, meaning quite a few contributions to the group’s work – over 300 000 gamers played the game and generated 33 million protein image classifications.

2018-11-01, NEWS

Sixteen new Technology Development Projects (TDPs) announced

To contribute in keeping SciLifeLab infrastructure at cutting-edge, a call for Technology Development Projects (TDPs)was opened during spring 2018. Now the sixteen projects, which will receive a total of 40 MSEK over a two-year period, are revealed. The purpose of the TDP initiative is to enable the development, exploration and optimization of new technologies in […]

2018-10-31, NEWS

Mapping the genome of the Aspen tree

After almost ten years of work, an international team, lead by researchers at Umeå University and SLU, has sequenced the entire genome of the two species of Aspen trees. Mapping a species’ gene set is often considered the key piece of the puzzle in biology as, when it’s done, all sorts of studies can be performed. The mapping of the human genome made way for a broad range of breakthroughs in the 21st century’s medicine and hopefully, mapping the Aspen tree’s genome will lay a foundation for many future studies in the area.

2018-10-29, NEWS

Single-cell RNA sequencing reveals platinum chemotherapy resistance gene

An RNA sequencing study led by Per Uhlén from Karolinska Institutet identifies the gene COX7B to be associated with cancer cell resistance to platinum-based chemotherapy, such as cisplatin. The results also demonstrate that the membrane-associated protein CD63 may be used as a surrogate marker for platinum resistance. Knock-down of COX7B in cancer cells decreased the sensitivity […]

2018-10-17, NEWS

Selfish genes causing fungal fratricide

Selfish genes, genes that are passed on through generations without any benefit to the individual, are thought to be an important driver of evolution. With support from the National Genomics Infrastructure at SciLifelab, researchers at Uppsala University have sequenced two selfish genes found in the fungus Neurospora intermedia, both of which cause fungal spores to kill their siblings.

2018-10-17, NEWS

Enhanced validation of antibodies for research applications

There is a need for standardized validation methods for antibody specificity and selectivity. In this paper, the researchers show that the five pillars involving orthogonal methods, genetic knockdown, recombinant expression, independent antibodies and capture mass spectrometry analysis, can be used to validate antibodies for Western blot applications in a standardized and systematic manner. The study […]

2018-10-16, NEWS

Adiponectin proposed biomarker for detection of Metabolic Syndrome

The hormone adiponectin is put forward as a useful diagnostic indicator of Metabolic Syndrome following a meta-analysis of existing scientific data from more than 7 000 individuals. The study, led by Adil Mardinoglu (KTH/SciLifeLab), shows that lower levels of circulating adiponectin in blood are highly associated with increased occurrence of Metabolic Syndrome – defined as […]

2018-10-09, NEWS

New knowledge about retrovirus-host coevolution

Retroviruses have colonised vertebrate hosts for millions of years by inserting their genes into host genomes, enabling their inheritance through generations as endogenous retroviruses (ERVs). A study led by Patric Jern, Uppsala University/SciLifeLab  now provide new knowledge about the long-term associations of retroviruses and their hosts by studying ERV variation and segregation in wild and […]

2018-10-08, NEWS

Ancient genomes suggest western Iron Age nomads originate from eastern Pontic-Caspian steppe

A team of scientists led by Anders Götherström from Stockholm University has utilized the services of the SciLifeLab National Genomic Infrastructure (NGI) to investigate the demographic dynamics in the Pontic-Caspian steppe – stretching from the northern shores of the Black Sea as far east as the Caspian Sea. Sequencing of 35 genomes of Bronze Age […]

2018-10-08, NEWS

Two culture-independent strategies for recovering bacterial genomes both generate accurate information

A study enabled by Microbial Single Cell Genomics shows that single-amplified and metagenome-assembled genomes both  generate accurate genome information from uncultivated bacteria.  Prokaryotes dominate the biosphere and regulate biogeochemical processes essential to all life. Yet, our knowledge about their biology is for the most part limited to the minority that has been successfully cultured. Molecular techniques now […]

2018-10-03, NEWS

Three big grants from Knut and Alice Wallenberg foundation

Three research projects coordinated by researchers at SciLifeLab recently got support from the Knut and Alice Wallenberg foundation. Together, the projects were granted more than 90 million SEK. Project: ”Translating mechanisms of cytotoxicity in natural killer cells and gamma-delta T cells into next generation cell-based cancer immunotherapy” Grant: 31 200 000 SEK for five years Main […]

2018-09-28, NEWS

SciLifeLab opens its doors to the future generation of scientists

As part of the yearly event Researchers’ Night (ForskarFredag), SciLifeLab in Stockholm welcomed around 280 high school students on September 28. Scientists from our research community gave presentations on their fields of work, such as small molecules, supercomputers, and personalized medicine. To top it all off, the students were invited for a tour of a […]

2018-09-25, NEWS

New way of blocking DNA repair in cancer cells after radiation therapy

Half of all cancer patients will get radiation therapy at some point of their treatment. A study led by Thomas Helleday and Nina Gustafsson, Karolinska Institutet/SciLifeLab, has found a new way of making cancer cells sensitive to radiation therapy. In the study, published din Nature Communications, the researchers show how they were able to block DNA […]

2018-09-21, NEWS

A new chemical probe for selective mass spectrometric analysis of the human gut microbiome

A new chemoselective metabolite modification technique for mass spectrometric investigation of metabolites in human samples has been developed by the laboratory of Daniel Globisch (Uppsala University/SciLifeLab). Application of this new multifunctional probe in human samples significantly improves mass spectrometric sensitivity and is a crucial tool for extending the scope of metabolomics research towards microbiota metabolism […]

2018-09-19, NEWS

Apply now for bioinformatics long-term support

Bioinformatics Long-term support (WABI) offers a senior bioinformatician to work in your project for up to 500 hours. The support is fully subsidized and free of charge, but extensive hands-on involvement is required by the applying research groups. To apply for support, you need to submit a small application about your project. More information along […]

2018-09-19, NEWS

Extended nomination period for the SciLifeLab seminar series

Who is the speaker of your dreams? The two SciLifeLab seminar series (SciLifeLab The Svedberg Seminar Series in Uppsala and SciLifeLab Seminar Series-Campus Solna in Stockholm) are now open for new nominations. Nominate a great speaker, a potential collaborator and/or superstar in your filed – SciLifeLab supports travel and acommodations up to two nights for leading […]

2018-09-13, NEWS

Networking across borders at NLSDays

Two days of inspiration and networking across industry, public and private sector borders, sum up the Nordic Life Science Days 2018 in a few words. SciLifeLab participated within the event through a dedicated satellite symposium, a workshop and an exhibition, all focusing on informing about the technologies and capabilities at SciLifeLab and how both academia […]

2018-09-12, NEWS

New neurons in the inner ear discovered

With support from the Eukaryotic Single Cell Genomics facility at SciLifeLab researchers at Karolinska Institutet have identified three types of neurons in the peripheral auditory system, which are new to science. The analysis of these cells can lead to new therapies for various kinds of hearing disorders, such as tinnitus and age-related hearing loss. The […]

2018-09-12, NEWS

Successful Satellite Symposium at NLSDays

On Monday the 10th of September, SciLifeLab hosted the satellite symposium SciLifeLab as a national resource for life science, in which almost 200 representatives from academia, industry and public sector in Europe, China and US took part.  The symposium was organized as a part of the Nordic Life Science Days 2018 and focused on introducing […]

2018-09-06, NEWS

National SciLifeLab Committee visited Solna

The members of the committee together with representatives from the SciLifeLab management (from left to right): Tommy Olsson (WCMM), Siv Andersson (Co-Director SciLifeLab), Mikael Sigvardsson (LiU), Jan Stenlid (SLU), Sara Hallin (alternate SLU), Lisbeth Olsson (Chalmers), Maria Fällman (UmU), Johan Malmström (alternate LU), Gunilla Westergren-Thorsson, chair (SciLifeLab Board) and Olli Kallionemi (Director SciLifeLab).  On September 5th, the National […]

2018-09-03, NEWS

New student class starts joint Master’s programme

This morning, around 30 students arrived at SciLifeLab in Solna for their first day of the Master’s Programme in Molecular Techniques in Life Science. We would like to welcome them and wish them a great two years at Karolinska Institutet, Stockholm University, KTH Royal Institute of Technology  – and, of course, at SciLifeLab. The Master’s […]

2018-08-30, NEWS

Novel method for identification of atherosclerosis biomarkers

Atherosclerosis can be developed for decades without any symptoms and when the disease becomes unstable myocardial infarction or stroke can be the first signs of the disease. Clinical tools like blood tests and image diagnostics are therefore required to improve prevention of myocardial infarction and stroke. In a study involving several researchers at SciLifeLab as well as […]

2018-08-28, NEWS

Controlled attachment and detachment of cargo from protein capsids for targeted delivery

Stefan Wennmalm at the Advanced Light Microscopy facility at Scilifelab has used FCS to show that protein binding to the inside of virus capsids can be controlled by calcium. The study was led by Ingemar André at Lund University and is published in Angewandte Chemie International Edition.

2018-08-24, NEWS

Dramatic development of immune system after birth

When a baby is born its immune system starts to change dramatically in response to its new environment, Petter Brodin (Karolinska Institutet/SciLifeLab) and colleagues report in a paper published in Cell. The study was made possible using new techniques of immune cell analysis at SciLifeLab. “This is the first time we’ve pinned down how the human […]

2018-08-23, NEWS

Loss of sleep alters metabolism and body composition

An international research team involving researchers from Karolinska Institutet, Stockholm University, Uppsala University and SciLifeLab have shown that one nights loss of sleep affects tissue metabolism and the regulation of gene expression in humans. These results published in Science Advances, might explain how chronic loss of sleep can promote weight gain and loss of skeletal muscle […]

2018-08-17, NEWS

First genomic insights into prokaryotic endosymbioses from the archaeal domain of life

By studying the genomes of two endosymbiotic interactions between ciliates and methanogenic archaea, Thijs Ettema (Uppsala University/SciLifeLab) and colleagues have got the first insights into prokaryotic endosymbioses from the archaeal domain of life. Sequencing was performed by the National Genomics Infrastructure, NGI, at SciLifeLab. Endosymbiosis is the phenomenon of one organism living within the body or cells of another organism […]

2018-08-16, NEWS

Deciphering microbiota metabolism in humans

A new methodology for the selective mass spectrometric investigation of gut microbiota and human host co-metabolism has been developed by the laboratory of Daniel Globisch (Uppsala University/SciLifeLab). This investigation led to the discovery of a large number of previously unidentified metabolites and represents a tremendous potential for the identification of unknown mediators of disease development. […]

2018-08-15, NEWS

Novel method sheds light on cell development

Researchers at Karolinska Institutet and Harvard Medical School led by Sten Linnarsson (Karolinska Institutet/SciLifeLab) report in Nature that they have developed a technique to capture dynamic processes in single cells. The method can be used to study disease processes and to observe how specialized cell types are formed during embryogenesis. The new method is built on […]

2018-08-15, NEWS

New reversibly photoswitchable fluorescent protein for nanoscale imaging of living cells

Reversibly photoswitchable fluorescent proteins (rsFPs) are gaining popularity as tags for optical nanoscopy because they make it possible to image with lower light doses. However, green rsFPs need violet-blue light for photoswitching, which is potentially phototoxic and highly scattering. Ilaria Testa (KTH/SciLifeLab) and colleagues have developed new rsFPs based on the monomeric red fluorescent protein FusionRed, […]

2018-08-14, NEWS

Three SciLifeLab researchers receive ERC Starting Grants

Alexey Amunts, Tove Fall and Oskar Karlsson receive the prestigious Starting Grant from the European Research Council, ERC. Project funding amounts to up to 1.5 million euros each. The purpose of the ERC Starting Grant is to encourage talented young research leaders in Europe to become independent and build their own careers. This year, 403 […]

2018-08-14, NEWS

New insights in the mechanisms of chemical chaperone

Trimethylamine-N-oxide (TMAO) enables certain marine organisms to live under conditions that would otherwise destroy their cells, and can even protect unstable human proteins like the tumor suppressor p53. A new study by Michael Landreh, David Lane, Sonia Laín, (all at Karolinska Institutet/SciLifeLab) and co-workers, shows that TMAO acts like a shield against harmful proteins, pushing them […]

2018-06-27, NEWS

Grant from Bill & Melinda Gates Foundation to investigate sepsis

By diagnosing infections in a simple and effective way many human lives can be saved. Mats Nilsson, Stockholm University/SciLifeLab, and his research group have now been granted more than 1 million SEK by the Bill & Melinda Gates Foundation to develop a method for examination of children with sepsis. Blood-poisoning, sepsis, is a life threatening […]

2018-06-26, NEWS

Brain morphology of wild and domestic rabbits differs remarkably

An international research team led by Leif Andersson (Uppsala University/SciLifeLab) has studied how domestication has affected brain morphology in rabbits. The results, published in PNAS, show significant differences in brain morphology between domesticated and wild individuals. Brain regions involved in fear processing, the amygdala and medial prefrontal cortex were particularly affected.  The most characteristic feature […]

2018-06-21, NEWS

Killing two birds with one stone: dual target compounds possible treatment of Parkinson’s disease

A recent study led by Jens Carlsson (Uppsala University/SciLifeLab) has identified two candidate drug compounds for treatment of Parkinson’s disease. Each of the compounds act on two different molecular targets, an approach that can achieve greater efficacy compared to single-target therapies. Parkinson’s disease is a long-term degenerative disorder of the central nervous system that lead to symptoms […]

2018-06-20, NEWS

AI for prostate cancer analysis

A new study led by Joakim Lundeberg (KTH/SciLifeLab) demonstrates that tumor heterogeneity in prostate cancers can be characterized using an AI approach. The results are published in Nature Communications.   Each cancer is unique and also alters its features as it progresses. The underlying genetic changes of this heterogeneity can be of clinical relevance to cancer […]

2018-06-12, NEWS

Cold-water sponges from different geographical areas share the same microbiota

In a novel study researchers have compared the microbiota of two species of sponges belonging to the genus Mycale from the sub-Antarctic Magellan region and the Western Antarctic Peninsula. High throughput sequencing performed by SciLifeLab National Genomics Infrastructure revealed a remarkable similarity in the microbiota of Mycale (Aegogropila) magellanica and Mycale (Oxymycale) acerata, although they live in geographically distant areas with contrasting environmental […]

2018-06-12, NEWS

Dog skeletal cancer genomics resembling human counterpart

The genes TP53 and SETD2 are often mutated in dogs suffering from skeletal cancer, according to a novel study led by Kerstin Lindblad-Toh (Uppsala University/SciLifeLab). The pattern found is similar to the ones in human skeletal cancers; clearly establishing that knowledge from canine studies can contribute to understanding of corresponding diagnoses in humans. Skeletal cancer is […]

2018-06-12, NEWS

Therapeutic gene editing may increase cancer risk

Using the recognized DNA-altering CRISPR-Cas9 technique to treat diseases may inadvertently increase the risk of cancer, according to a new study co-supervised by Bernhard Schmierer (Karolinska Institutet) who heads the High Throughput Genome Engineering facility at SciLifeLab. The results are published in Nature Medicine. CRISPR-Cas9 is a molecular machine that can be programmed to find a precise […]

2018-06-11, NEWS

SciLifeLab mobilizes expertise and technologies around seven research themes

To facilitate internationally competitive, cutting-edge collaborative research, SciLifeLab now announces its support for seven Research Community Programs – networks that will connect top researchers across Sweden with each other and with the SciLifeLab infrastructure. In February 2018, SciLifeLab launched a national call for Research Community Programs (RCPs) and seven applications from different research areas were […]

2018-06-08, NEWS

Ectomycorrhizal fungi play contrasting roles in decomposition of organic matter

A recent study enabled by the National Genomics Infrastructure shows that ectomycorrhizal fungi play contrasting roles in decomposition of organic matter. The researchers, led by Björn D. Lindahl at Swedish University of Agricultural Sciences (SLU), showed that exclusion of tree roots and associated ectomycorrhizal fungi in a boreal forest increased decomposition of surface litter by 11%. On the […]

2018-05-18, NEWS

Phospholipid beads alternative for estimating drug binding inside cells

A novel study led by Per Artursson (Uppsala University/SciLifeLab) demonstrates that phospholipid content within cells is a major determinant for how large portion of an administered drug that is available to exert its action. It also suggests pure phospholipid beads as a cell-free alternative for assessing drug binding in cells. The results are published in […]

2018-05-15, NEWS

Lennart Philipson award to Mikael Sellin

Mikael Sellin has been granted the Lennart Philipson award 2018 for his innovative work on bacterial gastrointestinal infections. He has developed a unique organ model for studying how bacteria, like Salmonella, penetrate cells in the intestine and how they interact with cellular components. The grant sum is SEK 1 million per year for two years, including a […]

2018-05-14, NEWS

Business council delegation from Saudi Arabia visits SciLifeLab

As part of the third annual meeting of the Saudi-Swedish Joint Business Council (SSJBC), a business council delegation from the Saudi Chamber of Commerce visited SciLifeLab Solna on May 9 to learn more of the research and innovation taking place in the Swedish life science sector. ____ The delegation was greeted by Strategic Relations Officer Lars […]

2018-05-14, NEWS

Precision Cancer Medicine focus of SciLifeLab seminar at Keystone Symposia

On May 9, SciLifeLab arranged a lunch seminar on Cutting-Edge Technologies in Precision Cancer Medicine during the three-day Keystone Symposia taking place in Stockholm. The conference was also co-organized by SciLifeLab. The seminar featured several researchers and facilities from SciLifeLab, highlighting large-scale sequencing efforts carried out in different cancer types, which have paved the way […]

2018-05-09, NEWS

Swedish Microfluidics Network launched at SciLifeLab

A network for the promotion of research and education in microfluidics was recently launched at a conference at SciLifeLab. Microfluidics is a research area that deals with fluids on the micrometer scale, the scale of human cells. Microfluidics is a key enabling technology for genomics and point-of-care (POC) diagnostics and is finding uses throughout the […]

2018-05-07, NEWS

Japanese delegation visits SciLifeLab

A large delegation from Japan including Toshimitsu Motegi (minister for economic revitalisation and economic reform) and Jun Yamasaki (Japanese ambassador to Sweden) visited SciLifeLab in Solna on Thursday May 3rd as a part of the minister’s visit to Sweden during the week. The delegation was introduced to SciLifeLab and it’s key focus areas, ongoing collaborations between […]

2018-05-04, NEWS

Laying the foundation for a precision medicine approach to treat glioblastoma – a SciLifeLab National Sequencing Project

  Five months ago, a glioblastoma sequencing study led by Professor Karin Forsberg Nilsson was granted funding through the SciLifeLab National Projects initiative. We met her at the Rudbeck Laboratory in Uppsala to learn more about the team’s work to advance the knowledge of this particularly aggressive form of brain cancer. A few weeks ago, the very […]

2018-04-26, NEWS

Rewriting the story of how mitochondria emerged

A study led by Thijs Ettema (Uppsala University/SciLifeLab) indicates that mitochondria evolved from a completely different type of proteobacteria than previously suggested. The results are published in Nature. For many years it has been proposed that mitochondria, organelles with a central role in both cellular energy production and apoptosis, originate from an aerobic alphaproteobacteria that […]

2018-04-26, NEWS

Chemical and Genetic Screening in focus at Science Summit 2018

On April 25, SciLifeLab hosted our annual Science Summit in Aula Medica in Solna. This years headline was Chemical and Genetic Screening – Exploring the Future Frontiers of Human Health, which attracted an audience of 300 people. In addition to the program, featuring both national and international speakers in the field, visitors could also deepen their knowledge […]

2018-04-20, NEWS

Novel virus found in mosquitoes from Mozambique

A research team from the Swedish University of Agricultural Sciences (SLU) has discovered a new type of virus. Upon RNA sequencing of mosquito samples from Mozambique using the SciLifeLab National Genomics Infrastructure, they were able to detect a previously uncharacterized virus similar to Picornavirales, which are known to infect a broad range of hosts. The […]

2018-04-16, NEWS

Rickard Sandberg receives the Göran Gustafsson prize

Rickard Sandberg, SciLifeLab faculty and Co-Founder of the Eucaryotic Single Cell Genomics facility, has been awarded the Göran Gustafsson prize 2018. The prize sum is 4.5 million SEK in research funding as well as a personal prize of 250 000 SEK. Nominations for the prize is made by Swedish universities and the awardees are appointed […]

2018-04-10, NEWS

Alexey Amunts receives 2018 Cancer Society Junior Investigator Award

Alexey Amunts (Stockholm University/SciLifeLab) is one of four early career investigators selected to receive a six-year research support from the Swedish Cancer Society, Cancerfonden. His research group studies how proteins are synthesized, folded and assembled into functional multicomponent membrane complexes that drive the cellular energy production, processes reportedly upregulated in cancer. Alexey Amunts is also […]

2018-04-09, NEWS

Gene expression patterns during regeneration in the Stentor ciliate differs between cellular areas

An RNA-sequencing study led by Thijs Ettema (Uppsala University/SciLifeLab) reveals that the cellular regeneration process of the ciliate Stentor polymorphus brings about a massive transcriptional response. These gene expression changes are also demonstrated to differ significantly between the front and back part of the organism. Ciliates are water-living unicellular eukaryotic organisms, characterized by the presence of hair-like […]

2018-04-09, NEWS

Genetic heterogeneity between distinct bone marrow compartments shown in AML

For the first time researchers have investigated intratumoral genetic heterogeneity between anatomically distinct bone marrow compartments of the same patient with acute myeloid leukemia (AML). The researchers, led by Olli Kallioniemi, Director of SciLifeLab and faculty at Karolinska Institutet/SciLifeLab, used exome and amplicon sequencing to compare biopsies from three different bone marrow compartments of two […]

2018-04-04, NEWS

Cryo-EM uncovers structure of energy-making components in green plants

The labs of Alexey Amunts and Erik Lindahl (both Stockholm University/SciLifeLab) have successfully determined the structure of chlororibosomes using Cryo-EM, providing novel insights into plant protein synthesis and a new perspective on the evolution of translation. This new study is published in Nature Plants.  The chlororibosomes are ribosomes located in the chloroplast organelles of plants […]

2018-04-03, NEWS

New insight about how viruses use host proteins to their advantage

Viruses have a very limited set of genes and therefore must use the cellular machineries of their hosts for most parts of their growth. A new study, led by Göran Akusjärvi and Leif Andersson, both at Uppsala University/SciLifeLab, has discovered a specific host protein that many viruses use for their transport within the cell. The results were published […]

2018-03-27, NEWS

Study identifies proteins coupled to survival in tonsillar and base of tongue cancer caused by HPV infection

A recent study by Torbjörn Ramqvist at Karolinska Institutet presents new potential strategies for treatment of certain types of tonsillar and base of tongue cancer. The expression of 155 proteins is analyzed in samples from both tumors and normal tissue using the SciLifeLab Clinical Biomarkers facility and National Bioinformatics Infrastructure Sweden (NBIS). A major factor causing […]

2018-03-23, NEWS

CDK2 inhibitor overcomes melanoma resistance against BRAF and Hsp90 inhibitors

A research team led by Gianluca Maddalo (KTH), involving several researchers at SciLifeLab, has discovered that melanoma resistance against BRAF and Hsp90 inhibitors can be overcome by implementing the current BRAF/MEK inhibitors therapy with a CDK2 inhibitor, dinaciclib, already used in clinical trials. Thermal proteome profiling (TPP) identified the protein targets of the Hsp90 inhibitor […]

2018-03-22, NEWS

Young researchers visit SciLifeLab

A group of 25 students from Swedish highschools visited SciLifeLab on Wednesday. The visit is part of the Young Researcher’s organisation Unga Forskare annual research expo competition. During their visit to SciLifeLab they listened to talks from Tanja Slotte, Nicolas Fritz and Nina Gustafsson and made a short tour through the labs.

2018-03-21, NEWS

Science, career coaching and networking at first annual NMMP meeting

On March 14 and 15, the first annual meeting of the National Molecular Medicine Fellows Program (NMMP) took place at the IVA conference center in central Stockholm. This two-day meeting for young research group leaders offered career coaching activities, networking, research infrastructure information and a scientific symposium. The NNMP is a joint effort by SciLifeLab […]

2018-03-20, NEWS

New drug combination suppresses cancer cells from children’s brain tumor

A research team led by Fredrik Swartling (Uppsala University/SciLifeLab) has discovered that medulloblastoma, the most common type of malignant brain tumor in children, can be effectively suppressed by combining two treatment strategies, disrupting both the expression and stabilization of the protein MYC. The MYC protein acts as a transcription factor that governs the expression of many […]

2018-03-14, NEWS

Sure Archaeopteryx could fly!

Was the Late Jurassic Archaeopteryx was a ground-living dinosaur or a flying bird? This question has fascinated paleontologists for decades. An international team of researchers, including Sophie Sanchez at Uppsala University/SciLifeLab, have now used synchrotron microtomography to answer this question without destroying the precious fossils. The results, published in Nature Communications, show that the wings […]

2018-03-13, NEWS

Video protocol of new enzyme-free nanoparticle biosensor technique available

The performance of biosensors, analytical devices that converts biological responses into electrical signals, can be improved by including nanoparticles as detection reagents. A recent paper by Jorge Dias (KTH) and several other researchers at SciLifeLab presents a novel method that circumvent previous limitations such as the need for high surface densities of nanoparticles to acquire […]

2018-03-13, NEWS

Genetic prehistory of Iberia differs from central and northern Europe

In a multidisciplinary study published in PNAS, an international team of researchers combined archaeological, genetic and stable isotope data to encapsulate 4000 years of Iberian biomolecular prehistory. The team examined of the remains of 13 human individuals from the north and south of Spain, including genome sequencing of a 7 245 year-old farmer performed by NGI Uppsala […]

2018-03-09, NEWS

Human Cell Atlas takes first steps to understand early human development

Researchers from the global Human Cell Atlas (HCA) Consortium have sequenced 250 000 cells involved in early human development and preliminary data analysis is now underway. The Swedish part of the effort, called the Human Developmental Cell Atlas (HDCA) program, includes researchers from Karolinska Institutet, Stockholm University and KTH, focusing on brain, lung, heart and fetal development during the first 12 […]

2018-03-02, NEWS

Promising therapeutic approach for spinal cord injuries

Researchers at Karolinska Institutet report in Cell that they have found an important mechanism that explains the limited healing ability of the central nervous system, resulting in permanent functional deficits efter injury. Using the new knowledge, Christian Göritz at Karolinska Institutet and colleagues could improve functional recovery following spinal cord injury in mice. The study was enabled […]

2018-02-28, NEWS

The Svedberg Prize to Lynn Kamerlin

Lynn Kamerlin, Uppsala university/SciLifeLab, is awarded The Svedberg Prize 2018 for her innovative studies of enzyme reactions where she combines a broad spectrum of theoretical, physical and organochemical methods to understand the chemistry of complex enzyme mechanisms. The prize is awarded a distinguished researcher within biochemistry or molecular biology. The awardee should be under 40 years of […]

2018-02-26, NEWS

Stem cell mutations drive muscle ageing

The decline in skeletal muscle function associated with human ageing can be ascribed to an increasing number of mutations in satellite cells – the resident stem cells of skeletal muscle. This is demonstrated in a novel study led by Karolinska Institutet researcher Maria Eriksson and facilitated by the National Genomics Infrastructure (NGI) and the National […]

2018-02-26, NEWS

Gunnar von Heijne receives The Novozymes Prize

The 2018 Novozymes Prize has been awarded to Gunnar von Heijne, Stockholm University/SciLifeLab, for his scientific breakthroughs in studies of membrane proteins. He receives a sum corresponding to SEK 4 million. The Novozymes Prize aims to raise awareness of basic and applied biotechnology research and is awarded to recognize outstanding research or technology contributions that benefit the development […]

2018-02-23, NEWS

Genes involved in oyster shell formation identified

A novel paper by Pierre De Wit from the University of Gothenburg reveals 37 genes correlated with shell formation in the early development of Pacific oysters (Crassostrea gigas). The study, enabled by the National Genomics Infrastructure (NGI) and National Bioinformatics Infrastructure Sweden (NBIS) of SciLifeLab, utilized a RNA-Seq approach to map the process where unprotected oyster embryos […]

2018-02-23, NEWS

Bioinformatics blog – call for contributions

The SciLifeLab bioinformatics platform, NBIS, recently launched a blog and are now welcoming you to contribute to it. The aim is to create a good environment to write, share and discuss bioinformatics from different perspectives. It doesn’t matter if you are beginning your journey with bioinformatics, or if you are an established bioinformatician. It doesn’t matter […]

2018-02-22, NEWS

Call for Technology Development Projects open

SciLifeLab is pleased to open a call for Technology Development Projects (TDP) to empower development and optimization of technologies. “The purpose of the TDPs is to help SciLifeLab national infrastructure facilities offer improved and new services to their customers and to keep the SciLifeLab infrastructure profile at the cutting-edge.” Says Annika Jenmalm Jensen, Infrastructure Director at SciLifeLab. […]

2018-02-19, NEWS

Human fatty liver disease eased by carbohydrate-restricted diet

Reduced carbohydrate intake results in fast and sizeable reductions of liver fat and other cardiometabolic risk factors in individuals suffering from obesity and fatty liver disease. This is shown in a new paper by Adil Mardinoglu (KTH/SciLifeLab) and colleagues, enabled by the SciLifeLab Clinical Biomarkers facility. In the ten patients subjected to a restricted diet […]

2018-02-14, NEWS

Self-sampling could double the detection rate of women with risk for cervical cancer

Using self-sampling followed by HPV-test, twice as many women with cervical intraepithelial neoplasia-positive (CIN2+) could be identified compared to Pap smear cytology. This is the conclusion from a study led by Ulf Gyllensten, Uppsala University/SciLifeLab, published in British Journal of Cancer. Read full press release by Uppsala University (in Swedish) Read full scientific paper

2018-02-12, NEWS

Janne Lehtiö new Scientific Director at SciLifeLab

Professor Janne Lehtiö has been elected Scientific Director of the SciLifeLab management group, representing Karolinska Institutet. Janne Lehtiö is a SciLifeLab faculty member, leads research in the field of medical proteomics and is affiliated with the Department of Oncology and Pathology at his host university. He is also the Facility Director of the Chemical Proteomics & Proteogenomics […]

2018-02-08, NEWS

Nordic Cryo-EM network established

The newly established network CryoNet aims at connecting experts in cryo-electron microscopy at the universities in Stockholm, Umeå, Århus and Copenhagen. Two of the microscopes that will be part of network are located at SciLifeLab in Solna. “This effort is a good reinforcement of the research environment around cryo-electron microscopy at SciLifeLab.” Said Gunnar von Heine (Stockholm […]

2018-02-06, NEWS

Release 4 of the FunCoup database of functional coupling networks

A new version of the FunCoup database (http://FunCoup.sbc.su.se) has been released by a research team led by Erik Sonnhammer (Stockholm University/SciLifeLab). The database has been extended with networks inferred for six new species and for the first time also includes bacteria. To visualize subnetworks from queries, a new graphical network viewer is in place which […]

2018-02-06, NEWS

New technology for accelerated wound healing discovered

Researchers at Uppsala University and SLU led by Mia Phillipson, Uppsala University/SciLifeLab, have discovered a new way to speed up wound healing. The technology, published in PNAS, involves using lactic acid bacteria as vectors to produce and deliver a human chemokine on site in the wounds. “We have developed a drug candidate, a next-generation biologic […]

2018-02-05, NEWS

Heterogenous tumors increase risk of fatal breast cancer

Patients with estrogen receptor (ER)-positive disease have a long-term risk for fatal breast cancer, but he biological factors are unknown. To investigate whether high intratumor heterogeneity of ER is associated with this increased risk, users of the SciLifeLab Tissue Profiling facility studied the tumors of 1780 postmenopausal women and the patients’ survival rate. The results […]

2018-02-01, NEWS

SciLifeLab signs Memorandum of Understanding with European Lead Factory

The SciLifeLab Director and European Lead Factory executives have signed a Memorandum of Understanding for collaboration in future initiatives. SciLifeLab and the EU Lead Factory, a collaborative public-private partnership aiming to deliver innovative drug discovery starting points by e.g. giving free access to up to 500,000 novel compounds, declare to exploit the complementarity and synergistic […]

2018-01-31, NEWS

Maria Strömme speaker at event during World Economic Forum

On January 24, SciLifeLab faculty member and Professor of Nanotechnology Maria Strömme (Uppsala University) was one of the invited speakers at the Swedish Lunch arranged during World Economic Forum (WEF) in Davos, Switzerland. WEF annually brings together some of the world’s most powerful and influential decision makers in politics and business. Read more in a […]

2018-01-25, NEWS

Finding unknown parts of a well-known intracellular pathway

In a new study led by Tobias Sjöblom (Uppsala University/SciLifeLab), a large-scale search for genetic mutations in human colorectal cancer cells made it possible to assign additional genes to intracellular pathways of clinical importance for the disease. Around 60% of human colorectal cancers have mutations in the KRAS, BRAF or ERBB genes – all of which […]

2018-01-22, NEWS

Postnatal neurogenesis in region of hippocampus mapped on single-cell level

A new paper from the Sten Linnarsson group (Karolinska Institutet/SciLifeLab) reveals that murine neurogenesis in the hippocampus proceeds through distinct stages, from the first weeks after birth into adulthood. The dentate gyrus, part of the hippocampus, is involved in learning, episodic memory formation and spatial coding. It is known as a brain region in which […]

2018-01-19, NEWS

Harmful genetic consequences from self-fertilizing plants spreading quickly

Climate change, leading to rapid changes in the geographical distribution of species, may cause losses in genetic variation and accumulation of destructive mutations. A new study by the group of Tanja Slotte (Stockholm University/SciLifeLab) and collaborators highlights why this is particularly problematic for self-fertilizing plants. The results are published in PNAS.  The researchers were able to […]

2018-01-19, NEWS

Novel method for discovering viral genomes in human metagenomic data

A computational strategy for finding novel viral genomes developed by a research team led by Erik Sonnhammer (Stockholm University/SciLifeLab), Björn Andersson (Karolinska Institutet/SciLifeLab), and Tobias Allander (Karolinska Institutet) was used to identify a number of protein families, lacking previously known homologs, in human samples such as serum, feces and cerebrospinal fluid.The study, published in Scientific Reports, identified a […]

2018-01-19, NEWS

Lessons from a flying membrane protein benefit anti-cancer drug development

It is now possible to determine the molecular structure of membrane proteins, previously difficult to characterize, offering better possibilities of developing pharmacological inhibitors for treating cancer and other diseases.  Turning off enzymes that are important for the survival of growing cells is a promising strategy to fight cancer. But to be able to shut down […]

2018-01-18, NEWS

New way to target the growth of breast cancer cells

The recently discovered protein NUDT5 is now presented as a candidate target for development of breast cancer treatment after being demonstrated to stop breast tumor cell growth in laboratory experiments. The research was led by Thomas Helleday (Karolinska Institute/SciLifeLab) and the results are published in Nature Communications.  Many breast cancers use hormones, such as oestrogen, to drive their […]

2018-01-17, NEWS

Petter Brodin new member of Wallenberg Clinical Fellows program

SciLifeLab congratulates Petter Brodin (Karolinska Institutet/SciLifeLab) to being included as a member of the Wallenberg Clinical Fellows program. It entails a three-year funding grant, financed by the Marianne and Marcus Wallenberg Foundation. The Royal Swedish Academy of Sciences (KVA) is responsible for the scientific evaluation. The Wallenberg Clinical Fellows program aims to stimulate clinical research among Swedish physicians, […]

2018-01-15, NEWS

The genomics behind the success of a wood decay fungus

A novel paper led by Inger Skrede (University of Olso, Norway) reveals a number of features that can explain why the dry to fungus Serpula lacrymans is the most successful invasive wood decay fungus in the built environment. The sequencing was performed at the SciLifeLab National Genomics Infrastructure (NGI) in Uppsala.  Not all species is negatively affected by habitat destruction […]

2018-01-12, NEWS

Genomic data indicate two main migration routes into Scandinavia following the last ice age

A novel study led by Mattias Jakobsson (Uppsala University/SciLifeLab) suggests that migrants settling down in Scandinavia after the last ice age initially came from the south, but later also from the northeast. As the groups met and mixed, a new population displaying patterns of genetic adaptation to high latitude environments arose. When the ice sheet […]

2018-01-12, NEWS

Chaperone turns into a gene regulator to permit cell growth

A novel study led by Kristina Jonas (Stockholm University/SciLifeLab Fellow) shows that the molecular chaperone DnaK (Hsp70) is required for growth in the fresh water bacterium Caulobacter crescentus, but that the specific function of DnaK differs depending on the environmental conditions of the cells. DnaK belongs to a group of proteins called heat shock protein, which have counterparts […]

2018-01-10, NEWS

Salamander genome gives clues about ability to rebuild tissue

A research team led by András Simon at Karolinska Institutet have managed to sequence the giant genome of a salamander, containing six times more DNA than the human genome. The project was enabled by sequencing at the SciLifeLab National Genomics Infrastructure (NGI) and SciLifeLab Bioinformatics services. Amongst the early findings is a family of genes that can provide clues to […]

2018-01-10, NEWS

Dan Larhammar elected new Preses of KVA

SciLifeLab congratulates Professor Dan Larhammar (Uppsala University/SciLifeLab) as he has been elected the new Preses of The Royal Swedish Academy of Sciences (KVA), an independent organisation whose overall objective is to promote the sciences and strengthen their influence in society. Dan Larhammar leads research in the fields of comparative genomics and neuroscience. Read the news text from KVA