News - 2019


2019-03-21, NEWS

Visit from the SciLifeLab International Advisory Board (IAB)

On March 13 to 15, SciLifeLab’s International Advisory Board visited SciLifeLab for the third time. The board visited SciLifeLab’s venues in both Stockholm and Uppsala to evaluate the operations and give advice on how we can develop even further.

2019-03-21, NEWS

Marc Friedländer traces origins through microRNA

The number-loving computational biologist and smørrebrød master Marc Friedländer and his research group has recently discovered a way to tell what species tissue samples come from, by using microRNAs. Now they set out to revolutionize the field. Marc Friedländer is a computational biologist and thereby spends most of his days at his computer. When asked […]

2019-03-19, NEWS

Premature children show adequate amount of maternal antibodies

In human newborns IgG antibody production starts 15 weeks after birth rendering them completely dependent on maternal antibodies transferred across the placenta during pregnancy, a phenomenon known as passive immunity. The concentration of maternal IgG in the fetus increases dramatically during the third trimester which has led to the belief that prematurely born children mostly […]

2019-03-11, NEWS

Genetic testing of colorectal cancer of low value before the age of 40

A study published in Molecular Genetics & Genomic Medicine concludes that the chance of detecting a hereditary cancer syndrome in young colorectal cancer patients is low. The study was enabled by the SciLifeLab National Genomics Infrastructure (NGI). Colorectal cancer is the third most common cancer diagnosed in Sweden. Development of the disease before the age […]

2019-03-05, NEWS

SciLifeLab-AstraZeneca collaboration maps gene expression in heart failure

In the SciLifeLab/AstraZeneca collaboration on heart failure, a study has been published in Scientific Reports (https://rdcu.be/boOId) on mRNA expression in myocardial biopsies, obtained from patients undergoing elective coronary bypass surgery, as part of the large study named PREFERS (Preserved and Reduced Ejection Fraction Epidemiological Regional Study). The study was led by SciLifeLab researcher Bengt Persson […]

2019-03-04, NEWS

Few genes involved in the wall lizard’s different traits

Different colored lizards of the same species differ in size, fighting ability and reproductive strategies – due to variation in only two genes, shows a study led by researchers from Uppsala University and the University of Porto. The study was enabled by the SciLifeLab National Genomics Infrastructure (NGI). Reptiles show a diverse range of colors […]

2019-02-28, NEWS

New findings could help children with growth disorders

Researchers at Karolinska Institutet have discovered that bone growth in mice functions the same way new cells are being produced in blood, skin and other tissue – not a fixed number of “growing cells” that run out and we stop growing, as previously thought. The study was enabled by the SciLifeLab National Genomics Infrastructure (NGI). […]

2019-02-27, NEWS

Portal to help interpret cancer data developed – first patients selected

The first patients have been selected for precision cancer therapy using the Molecular Tumor Board portal, a platform to support clinical decisions based on the genomics profile of the tumors. The Molecular Tumor Board portal is developed by researchers at Karolinska Institutet and SciLifeLab to help clinicians interpret biological cancer data and select the most […]

2019-02-26, NEWS

New skeletal disease uncovered

A group of researchers led by physician and Associate Professor Giedre Grigelioniene (Karolinska Institutet) have identified a previously unknown skeletal dysplasia. The study, now published in Nature Medicine, describes the molecular mechanism behind this rare condition. Their analyses were enabled by a SciLifeLab Clinical Genomics facility. A mother and her child had come to the clinic […]

2019-02-25, NEWS

More paternally expressed genes than previously thought

A recent study, published in Genome Biology, shows that there are substantially more paternally expressed genes in the endosperm of the plant Arabidopsis than what has previously been identified. This indicates that paternal-specific gene expression is of higher functional relevance than previous estimates. Genomic imprinting is an epigenetic phenomenon causing maternal and paternal alleles to […]

2019-02-22, NEWS

Evolution of common weed depends on parental legacy

A recent study led by Martin Lascoux (SciLifeLab/Uppsala University) shows how the evolutionary trajectory of a newly formed tetraploid species of plant closely depends on its parental legacy and on DNA presence from its diploid relatives. Most plant species have a polyploid origin, and many of them are allopolyploid species, which means that they originated […]

2019-02-18, NEWS

Less snow may hasten climate change

According to a new study, published in mSphere and led by SciLifeLab Fellow Sari Peura, a decreased snow cover on lakes increase the levels of methane, something that may hasten climate change. Climate change may lead to less snow covering lakes in boreal and subarctic regions. Forest lakes are substantial contributors of methane emissions, and research […]

2019-02-18, NEWS

Absent protein potential target for diabetes drug treatment

Knowledge of a newly discovered genetic disorder can lead way to development of new diabetes drugs. This is shown in a study co-led by SciLifeLab researcher Anna Wedell (Karolinska Institute) and published in the journal Diabetes. The newly discovered genetic disorder, with high levels of lactic acid and low levels of the amino acid methionine in […]

2019-02-13, NEWS

The inflammatory shift of pregnancy

During pregnancy, the female body must balance the act of protecting the fetus against harmful microorganisms and maintaining a tolerance to paternal antigens from the fetus, in order to prevent rejection. In a novel paper by researchers from Uppsala University, a large shift in inflammatory status of women in late pregnancy and around two months […]

2019-02-12, NEWS

SciLifeLab enables genome sequencing breakthrough

A research group at Karolinska Institutet has sucessfully mapped three extremely complex chromosome aberrations by using pieces from four different DNA analyses. The project has received support from the SciLifeLab Swedish Genomes program. Researchers have spent two years trying to figure out what the genetic causes are for the severe symptoms that three individuals have […]

2019-02-12, NEWS

Small groups with big impact: antibiotic heteroresistance more common than thought

When selecting antibiotics for treatment of bacterial infections, physicians often rely on regular drug sensitivity tests conducted on bacterial samples from the patients. Still, treatments are sometimes unsuccessful. A new study led by Dan Andersson from Uppsala University provides evidence that heteroresistance, the presence of a resistant subpopulation in a main population of susceptible cells, is […]

2019-02-11, NEWS

SciLifeLab researchers among the most highly cited

Clarivate Analytics recently published their list of highly cited researchers from 2018. In total, 62 researchers from Sweden were on the list, and among them are five from SciLifeLab: Jens Nielsen (Facility Director at Systems Biology in Gothenburg), Rickard Sandberg, (Facility Director at Eukaryotic Single Cell Genomics), Erik Sonnhammer (Stockholm University), Ann-Christine Syvänen (Uppsala University, and Facility Director at […]

2019-02-11, NEWS

Receptor insights may lead way to custom-made cancer treatment

A recent study published in Nature Communications, co-authored by SciLifeLab Fellow Jens Carlsson (Uppsala University), has identified how a group of G protein-coupled receptors is affected by cancer mutations. This may lead to new drugs being developed. Class F, or Class Frizzled, is a group of of G protein-coupled receptors that are considered valuable therapeutic targets due […]

2019-02-11, NEWS

Molecular basis for the variability of mitoribosomes across species revealed

A collaborative effort between researchers from SciLifeLab, Georgia Institute of Technology and Harvard Medical School has revealed why mitochondrial ribosomes are highly variable across species. The study published and featured on the cover of the journal of Molecular Biology and Evolution, was led by SciLifeLab Fellow Alexey Amunts (Stockholm University/Karolinska Institutet), who also heads the cryo-EM lab. Despite a common ancestry, […]

2019-02-08, NEWS

Fat mass and fat-free mass found to have independent effects on atrial fibrillation

A recent study led by Erik Ingelsson (Uppsala University/SciLifeLab) has explored the association between body composition and atrial fibrillation – a common type of arrhythmia, or irregular heart rhythm. The effect of fat mass was shown to be independent, not mediated through the effect of fat-free mass. A globally aging population and growing obesity numbers […]

2019-02-06, NEWS

Ten Million Euro for Access to European Proteomics Facilities

The European Union has awarded 10 million euro to a consortium of eighteen European research groups in the field of proteomics research throughout Europe. One of these eighteen partners is the SciLifeLab Cell Profiling facility, offering spatial mapping of proteins at high resolution in cells and tissues. The European Proteomics Initiative Consortium (EPIC-XS), funded as part […]

2019-02-06, NEWS

SciLifeLab researchers explore environmental pollution and associated health risks in Bangladesh

The Swedish Research Council (VR), Sida, Formas and Forte have recently awarded funding for research on environmental pollution and associated health risks in Bangladesh. Oskar Karlsson and Jonathan Martin (Stockholm University/SciLifelab) were granted 5.6 million SEK to explore these issues. “The overall goal of our project is to screen, identify and determine levels of organic […]

2019-02-05, NEWS

Horses’ trotting racing ability undoubtedly polygenic

A recent study published in BMC Genomics has explored the genetics of trotting racing ability in horses. The study identified hundreds of candidate regions contributing to the horses’ trotting racing ability, which was described as “undoubtedly polygenic”. The results further suggest that racing ability may be a product of mental characteristics, not only physical ones. […]

2019-02-05, NEWS

Compressing entire labs into a computer chip

Once lab-on-a-chip (LOC) technology can be manufactured in a scalable cost-effective way, it could transform medicine in ways comparable with how microprocessors have changed our daily lives. In a new study reported in KTH News, a group led by SciLifeLab researcher Aman Russom (KTH) have developed a dispenser that could speed that revolution up.

2019-02-04, NEWS

Genes increase the risk of narcolepsy after Pandemrix vaccination

Genetic factors may increase the risk of severe unusual side-effects from the influenza vaccine Pandemrix. This was found in a recent study by the national project Swedegene, a collaboration between Uppsala University, Karolinska Institutet and the Swedish Medical Products Agency that study severe adverse reactions, with narcolepsy being one of them. The National Genomics Infrastructure (NGI) […]

2019-01-30, NEWS

8 million SEK to network for sample preparation expertise

An initiative to launch a network of regional hubs for sample preparation has been granted 8 million SEK in funding over four years from the Swedish Research Council (VR). Linda Sandblad, Head of Facility at the SciLifeLab Cryo-EM node at Umeå University, coordinates this project named NanoSPAM: National Nodes for Sample Preparation And Microscopy. It is […]

2019-01-30, NEWS

New method for rapid isolation of mitochondrial ribosomes

The group of SciLifeLab Fellow Alexey Amunts (Stockholm University/Karolinska Institutet) has published a new video on JoVE, describing their novel method for large-scale purification of intact ribosomes from human mitochondria. These mitoribosomes are central components of energy production, however their biochemical isolation was not well established. The described method, which has been developed at SciLifeLab, provides […]

2019-01-30, NEWS

Historical genomes reveal recent changes in eastern gorillas’ genetic health

The critically endangered Grauer’s gorilla, found in the Democratic Republic of the Congo, has declined by over 80 % in recent decades due to poaching and habitat destruction. The decline has resulted in harmful mutations and a loss of genetic diversity, according to a new study where historical and modern genomes of the gorilla have been compared.

2019-01-25, NEWS

Swedish forest soil microbes produce toxic mercury compound

The formation of the powerful neurotoxic methylmercury (MeHg) is a microbially mediated process that has raised much concern as it poses threats to both nature wildlife and human health. To understand the biogeochemical processes involved in the formation of this pollutant, researchers from Uppsala University have now mapped the microbial populations that contribute to MeHg […]

2019-01-25, NEWS

Newfound traits of myelin-producing cells in MS

In a recent study published in the journal Nature, researchers from Karolinska Institutet and the University of Edinburgh, UK, have investigated oligodendrocytes from deceased multiple sclerosis (MS) patients and discovered that subpopulations of these myelin-producing brain cells are altered in MS. The SciLifeLab Eukaryotic Single Cell Genomics facility enabled the determination of genetic activity of […]

2019-01-23, NEWS

Deeper knowledge of lichens’ complexity through DNA analysis

An individual lichen, which consists of fungi and algae living in symbiosis, can contain up to three different fungi. A discovery providing insight to another recent discovery showing lichens are made up of more than a single fungus and algae, overturning the prevailing theory of more than 150 years.

2019-01-21, NEWS

Genes influence where excess body fat is stored

A novel study led by Åsa Johansson (Uppsala University/SciLifeLab) reveals that genetic factors highly influence on whether your body stores fat around the arms, legs or trunk. The researchers have employed data from UK Biobank, a cohort study including half a million participants from the United Kingdom. Participants had given blood samples for genotyping as […]

2019-01-15, NEWS

SciLifeLab part of a major grant in forest genetic research

The Knut and Alice Wallenberg Foundation is investing over a 100 million SEK in research on tree genes, forest genetics and forest biotechnology. The project is a collaboration between SLU and SciLifeLab in Uppsala and Stockholm. The project focus on genomics and forest genetics and builds on a previous grant from the Knut and Alice […]

2019-01-14, NEWS

Restoring the differentiation and function in cryopreserved hepatocytes

Primary human hepatocytes are used in all areas of liver research, from in vitro studies of toxicity to clinically managing liver failure. The availability of these hepatocytes is, however, limited due to the problem of cellular stress during isolation and cryopreservation, causing a highly unpredictable loss of the ability to attach and form cell-matrix and […]

2019-01-14, NEWS

Subclasses of breast cancer-associated fibroblasts revealed

While cancer-associated fibroblasts (CAFs) are known to be a major constituent of the tumor microenvironment, their origin and roles in shaping disease initiation, progression and treatment response have remained unclear due to significant heterogeneity. Now, a research team led by Kristian Pietras from Lund University has discovered three distinct subpopulations of the cancer-associated fibroblasts.   […]

2019-01-11, NEWS

Olli Kallioniemi receives the Annual Research Prize of the Finnish Medical Society Duodecim

Photo: Mari Kaunisto Professor and SciLifeLab Director Olli Kallioniemi is a winner of the 2019 Matti Äyräpää Award. This prize is the most important national medical prize in Finland, which has been awarded annually by the Medical Society Duodecim since 1969. Olli Kallioniemi is awarded for his pioneering contributions to molecular precision medicine, to new technologies and […]

2019-01-09, NEWS

Advancing the understanding of endogenous DNA double-strand breaks

DNA double-strand breaks (DSBs) jeopardize genome integrity and might give rise to structural rearrangements associated with cancer, when repaired unfaithfully. In a new study led by SciLifeLab researcher Nicola Crosetto (Karolinska Institutet), a research team delves deeper into the matter. While exogenous agents such as chemotherapy and ionizing radiation can invoke the DSBs, a large amount […]

2019-01-07, NEWS

New analysis method for mapping proteins shared in an open database

A team of researchers at Karolinska Institutet and SciLifeLab have developed a new analysis method to map the localization of proteins in cells, information which they have shared in an open database accessible to researchers around the world. The study, published in Molecular Cell, was led by Professor Janne Lehtiö, SciLifeLab researcher and Facility Director for the SciLifeLab site of Chemical Proteomics & Proteogenomics.