News - 2020

2020-04-01, NEWS

A new atlas of human metabolism

The new Metabolic Atlas, which is part of the Human Protein Atlas (HPA), was recently described in Science Signaling. The map enables exploration of the human metabolism and is the most extensive metabolism map to date. Within the hundreds of new interactive 2D and 3D maps, information about thousands of reactions, compounds and human metabolism […]

2020-04-01, NEWS

Evolutionary genetics of canine corona virus in Swedish dogs

Enabled by the SciLifeLab National Genomics Infrastructure (NGI), researchers have investigated Canine respiratory coronavirus (CRCoV) in Swedish dogs. CRCoV is the main cause of upper respiratory infection in dogs in Sweden but the understanding of its global prevalence, pathology, and genetic characteristics is still dim. In a recent study, enabled by the SciLifeLab National Genomics […]

2020-03-31, NEWS

SciLifeLab researcher Johan Elf receives an ERC Advanced Grant

Today, the Swedish Research Council announced that Johan Elf (SciLifeLab/Uppsala University), is awarded an ERC Advanced Grant. He is one of 185 researchers who receives the grant, whereof only six are working in Sweden. The researchers will share a total amount of 450 million Euro. “I am very happy that we can start this exciting and […]

2020-03-31, NEWS

Large number of submissions to SciLifeLab COVID-19 call

The SciLifeLab Open Call for COVID-19-related Proposals is now closed. We have received an astonishing 285 submissions and will now commence the process of evaluating the proposals, identifying synergies and deciding which initiatives to support through this funding. Additional updates regarding the call will follow as information becomes available.

2020-03-26, NEWS

Cancer cells makes themselves vulnerable to new drugs

Researchers from SciLifeLab and Uppsala University have discovered a way to use the rapid mutation rate in cancer cells as a weapon against tumours. A new substance has shown promising results in both animal and human cancer cells. The results are published in Nature Communications. Normally cancer cells quickly alter their DNA, making them hard […]

2020-03-26, NEWS

Revealing new mechanisms of STAT3 inhibition

Facilitated by the SciLifeLab Chemical Biology Consortium Sweden (CBCS), researchers from Sweden and Canada have identified novel ways to inhibit STAT3 activity in cancer cells while revealing new mechanistic understanding of STAT3 biology. Transcription factor STAT3 plays an important role during cancer development and progression and has, because of this, become a popular target for […]

2020-03-25, NEWS

SciLifeLabs handlingsplan för COVID-19 lanserad – med utlysning till forskarsamhället / SciLifeLab COVID-19 Action Plan launched with open call to the research community

[Swe] Vilka steg tar SciLifeLab i kampen mot coronaviruset? De kan delas in i två huvuddelar – fokuserade på att testa och analysera SARS-Cov-2-viruset, och att bekämpa coronapandemin – som presenteras i den nyligen lanserade handlingsplanen. [Eng] What steps are SciLifeLab taking in the battle against the corona virus? They can be divided into two main parts – focused on testing the SARS-Cov-2 virus and combating the corona pandemic – which are presented in the newly launched Action Plan.

2020-03-23, PRESS

SciLifeLab bidrar till uppskalning av diagnostisering och analys av COVID-19

Igår, den 22 mars 2020, meddelande Knut och Alice Wallenbergs Stiftelse att de omgående anslår 50 miljoner kronor till akademiska laboratorier på SciLifeLab, Karolinska Institutet och Uppsala universitet för att bistå i sjukvårdens uppskalning av provtagning avseende coronavirussjukdomen COVID-19. ”SciLifeLab:s forskare vill och är redo att bidra i arbetet med den pågående COVID-19-pandemin på flera olika vis, både på kort sikt och längre fram.”

2020-03-20, NEWS

SciLifeLab infrastructure facilities prioritize COVID-19 projects

SciLifeLab service facilities are now encouraged to prioritize projects regarding COVID-19. As a national, government-funded research infrastructure in Sweden, SciLifeLab can make advanced technologies and expertise available to support researchers working on COVID-19. As always, feasibility and quality are key when our facilities approve applications for service. Are you conducting a COVID-19 project and unsure of which infrastructure […]

2020-03-19, NEWS

DNA from 1/3 of the Baltic Sea plankton catalogued

An international collaboration, led by Anders Andersson (SciLifeLab/KTH), has assembled the genomes of hundreds of bacterioplankton species from the Baltic Sea. In the study, published in Communications Biology, the researchers show that by having this large number of genomes from the same ecosystem, the ecological niche of individual species can be predicted directly from their […]

2020-03-16, NEWS

SciLifeLab releases 10-year strategy: Strong focus on technology- and data-driven life science

Ten years has passed since SciLifeLab was first launched and the importance of life science to all aspects of human life and society is ever so evident – not least from the ongoing pandemic crisis. SciLifeLab’s new Roadmap for the decade ahead pinpoints how our research infrastructure can be advanced and leveraged in creating multidisciplinary, […]

2020-03-11, NEWS

Cryo-EM reveals unexpected diversity of Photosystems

Researchers from SciLifeLab have reconstructed the atomic models of new forms of Photosystem I in collaboration with scientists from Tsinghua University (China) and Tel Aviv University (Israel). The studies, published in two Nature Plants articles, expand on the fundamental understanding of how bioenergetic complexes are assembled and regulated in the photosynthetic membranes of cyanobacteria and […]

2020-03-06, NEWS

One step closer to understand the human brain

An international team of scientists led by researchers from SciLifeLab and Karolinska Institutet has launched a comprehensive overview of all proteins expressed in the brain, providing neuroscience and medical research with a tool to explore proteins in different parts of the brain controlling basic and complex brain functions. The open-access database offers medical researchers an […]

2020-03-04, NEWS

Science & SciLifeLab Prize for Young Scientists – Application Period Open

In order to promote young scientists early in their career, SciLifeLab has engaged in a collaboration with AAAS and Science magazine to award an annual prize in the area of life science for the best PhD thesis work. An essay based on the thesis is submitted to the editorial board of Science and four winners […]

2020-03-03, NEWS

SciLifeLab researcher Petter Brodin awarded the Göran Gustafsson Prize

SciLifeLab researcher Petter Brodin (Karolinska Institutet), is awarded the prestigious Göran Gustafsson Prize in medicine for his “pioneering analysis of the early development of the human immune system”. “Our goal is to optimize the development of all children and find out what is a healthy start for them. There are many epidemiological studies showing that […]

2020-03-02, NEWS

New method sheds light on the role of RNA in chromatin regulation

Researchers from Karolinska Institutet, SciLifeLab and RIKEN (Japan) have developed a new method that can generate maps of RNA and chromatin interactions in the nucleus. This is particularly useful when studying how gene expression is regulated in different cells and tissues. Inside the mammalian genome, thousands of noncoding RNA:s can be found. Once transcribed, these […]

2020-02-25, NEWS

New rapid COVID-19 detection method developed

Researchers from Shenyang, Huazhong and SciLifeLab have developed a rapid colorimetric detection method for the COVID-19 coronavirus (iLACO). The approach is based on RT-LAMP (loop-mediated isothermal amplification) and allows a fast detection using a visual colorimetric assay (pink to yellow). The approach can detect down to 10 molecules of virus RNA in 15 to 40 […]

2020-02-25, NEWS

Creating cartoons to communicate science – Jonas Nørskov Søndergaard challenges what a scientific journal could be

Jonas Nørskov Søndergaard is, apart from being a cancer researcher at SciLifeLab, moonlighting with creating his own academic journal. What he thought was going to be an instant success turned out to require a lot more work, however. What seems to be a million steps awaits when entering the 1920’s apartment building, with its fair-faced […]

2020-02-24, NEWS

Revealing new details about P. infestans reproductive system

Facilitated by the SciLifeLab National Genomics Infrastructure (NGI) researchers from the Swedish University of Agricultural Sciences (SLU) have investigated the sexual reproduction system of the “potato late blight” pathogen Phytophthora infestans, one of the most notorious plant pathogens known today. Phytophthora infestans is a fungal-like filamentous pathogen that can infect many species in the Solanaceae […]

2020-02-18, NEWS

SciLifeLab Fellows appointed Future Research Leaders by the SSF

The Swedish Foundation for Strategic Research (SSF) has appointed the seventh generation of Future Research Leaders (FFL). From the 227 applications, 10 men and 10 women were selected, among them SciLifeLab Fellows Simon Elsässer (Karolinska Institutet) and Mikael Sellin (Uppsala University). The goal is to support and promote young scientists into becoming the future leaders […]

2020-02-17, NEWS

Dingos evolved from domesticated Indonesian village dogs

According to a study, led by SciLifeLab researcher Peter Savolainen (KTH), the Australian dingo derives from domesticated dogs. Scientists have long suspected this but up until now, no genomic studies to confirm the hypothesis have been conducted. Their migration to Australia began 9,900 years ago when they split off from their ancestors, the Indonesian village […]

2020-02-14, NEWS

The nf-core community provides computational pipelines

To help researchers analyse their data in a reproducible and accessible manner, researchers at SciLifeLab have created a community called nf-core, which provides best-practice bioinformatics analysis pipelines for use across any institute or research facility. The capacity for data-generation within life-sciences is growing rapidly, and with it the need for analysis methods to be FAIR […]

2020-02-13, NEWS

Researchers unveil the mechanism behind malaria sugar uptake

Researchers from SciLifeLab, among them SciLifeLab Fellow Lucie Delemotte (KTH),  and Stockholm University have unveiled the mechanism behind the malaria parasite sugar uptake, something that could be useful in the hunt for new drugs. Malaria is responsible for killing almost half a million people every year, according to the WHO. The Malaria parasite (Plasmodium falciparum) needs, […]

2020-02-05, NEWS

Whole genome sequencing from just six nuclei

Enabled by the SciLifeLab Microbial Single Cell Genomics facility (MSCG), National Genomics Infrastructure (NGI) and National Bioinformatics Infrastructure (NBIS), researchers from Uppsala University have developed a new and more effective way to sequence genomes from organisms that are otherwise hard to sequence. The reasons why some organisms are harder to sequence are usually because of […]

2020-01-29, NEWS

Supposedly “lethal” mutation makes bacteria resistant to rifampicin

Facilitated by the former SciLifeLab facility Mass Spectrometry-based Proteomics in Uppsala, researchers from Uppsala University have discovered how antibiotic-resistant tuberculosis manages to survive even though it carries a mutation that should kill it. Every year, tuberculosis (TB) is responsible for the deaths of 1.5 million people worldwide. It is normally treated with a combination of […]

2020-01-27, NEWS

Intestinal epithelial cells rarely tricked by Salmonella’s evasiveness

A study by researchers from SciLifeLab and ETH Zurich, Switzerland, sheds light on the defense mechanisms restricting Salmonella Typhimurium (S. Tm) from disseminating to systemic organs from the intestinal tract, following oral infection. Inflammasomes – signaling complexes that assemble when host cells detect invading pathogens – can prevent systemic dissemination of bacteria from the intestinal […]

2020-01-17, NEWS

New cheap drug targets therapy resistance in acute myeloid leukaemia

A common and inexpensive drug can be used to counteract treatment resistance in acute myeloid leukemia (AML), one of the most common blood cancer forms in adults, according to a study led by researchers from SciLifeLab and Karolinska Institutet. The study was published in the medical journal EMBO Molecular Medicine and the researchers will now […]

2020-01-14, NEWS

Coordinating safety – Jona Gudjonsdottir helps scientists stay safe

To help researchers work safely and avoid making the same life threatening mistakes she has made in the lab, Jona Gudjonsdottir uses her lifelong experience from various laboratories in her role as Lab Safety Coordinator at SciLifeLab. Before learning what Lab Safety Coordinator Jona Gudjonsdottir actually does for a living, for someone working at SciLifeLab […]

2020-01-13, NEWS

Sleep deprivation might increase the risk of Alzheimer’s disease

Facilitated by the SciLifeLab National Genomics Infrastructure (NGI), researchers have discovered that the blood levels of tau – a biomarker for Alzheimer’s disease – increases when the test subjects were deprived of just one night of sleep. Tau is a protein found in neurons that can form tangles and accumulate in the brains of people with […]

2020-01-08, NEWS

Computer algorithm finds new therapeutic target for neuroblastoma

Based on a new algorithm, TargetTranslator, researchers from SciLifeLab were able to identify a new therapeutic target for neuroblastoma, a form of cancer in the sympathetic nervous system. The algorithm integrates data from tumour biobanks, pharmacological databases, and cellular networks. Neuroblastoma is mainly affecting young children and is responsible for 15 percent of all childhood […]