Call for proposals: SciLifeLab National projects 2014


This call has now been closed.

The final decision on awarded projects has been announced.

 


Call for proposals: SciLifeLab national projects

SciLifeLab welcomes applications for the Swedish Genomes and Biodiversity programs.

Background
SciLifeLab is a center for large-scale biosciences with a focus on health and environmental research. The center combines advanced technical knowhow and state of the art equipment with a broad knowledge in translational medicine and molecular bioscience (www.scilifelab.se). The National Genomics Infrastructure (NGI) hosted at SciLifeLab offers large-scale DNA sequence data generation and analysis.

SciLifeLab now launches two national programs based on massively parallel DNA sequencing at NGI: The Swedish Genomes and Biodiversity Programs, to be in operation during 2014-2015.

SciLifeLab national projects aim to give significant sequencing support to Swedish scientists to carry out competitive international research. The total budget corresponds to 15 MSEK for program 1 and 5 MSEK for program 2.

Both programs will be launched as two consecutive calls, and the application deadline for the current, first call is May 15th, 2014.

National program 1: The Swedish Genomes Program
1A) Whole genome sequencing to identify the genetics causes of diseases of high health relevance. Projects can include studies of familiar cases of disease as well as case-control studies.

1B)  Establishment of a reference database of genetic variation in the Swedish population based on whole genome sequencing.

National program 2: The Biodiversity Program
Projects can target Biodiversity of viruses, bacteria, archaea and eukaryotes, and combinations thereof.

Terms and conditions for the grant

The grants in programs 1A and 2 will be awarded as a 50% deduction of sequencing reagent costs for projects carried out at NGI. For proposals relating to establishment of a national genetic variant reference database (1B) and for proposals from Junior Researchers, the complete costs will be covered by the grant. For Junior researchers the doctoral degree must be awarded 2007-01-01 or later (Deductions apply for parental leave, illness, residency and specialist training for clinically active professional groups, positions of trust in trade union organizations and student organizations in accordance with criteria applied by the Swedish Research Council).

Standard bioinformatics NGI support is provided, including assembly, mapping of reads, variant calling and basic functional annotation. In addition, SciLifeLab will support the project and ensure efficient handling of the data by providing assistance in coordinating and harmonizing studies from a technical and bioinformatics perspective.

Subsequently, awarded projects are welcome to apply for further bioinformatics support from the National Bioinformatics Infrastructure at SciLifeLab.

The applying party must assign at least one scientist from their group to be involved in the bioinformatics work to ensure efficient knowledge transfer and longevity of the project beyond the actual data generation.

The call is open for scientists at a Swedish university or higher education institution.

We anticipate supporting a limited number of projects of high scientific value. The minimal support that can be applied for is 200 TSEK.

Instructions for Applying

Application deadline: May 15th, 2014.

To electronic application

You are responsible for ensuring that the application is complete. Incomplete applications will not be processed. Attach only material that we expressly request. SciLifeLab does will not accept additional information after the closing date for applications, except for information we ourselves expressly request.

The total reagent costs for human genome sequencing is approximately 14 000 SEK given a 30 fold coverage of the human genome.  For cost estimates in the Biodiversity Program we refer to the NGI webportal 

A recording of a webinar on biodiversity sequencing possibilities at the National Genomics Infrastructure together with presentations in PDF format is available here.

Content of the Application

All documents should be in A4 format, using a 25 mm margin and a Times New Roman 12 font. All documents, except when explicitly stated should be in English.

  • Summary (Max 1500 characters).
  • Popular scientific description in Swedish (Max 1500 characters).
  • Research program (See further below) including a project title (Max 6 pages).
  • CV for main applicant (Max 2 pages).
  • List of the 10 most relevant publications the last five years for the main applicant.
  • Budget. Cost estimates for sequencing and account for available co-funding for sequencing reagent costs and bioinformatics support available in the applying group.
  • A statement from the Head of Department that co-funding is available if applicable.

Research program

The research program must include:

  • Background
  • Purpose and aims
  • Project plan
  • Significance
  • Ethical considerations including relevant ethical approval (Dnr)
  • Additional experimental and/or bioinformatics support needed, if applicable
  • Involvement. State the current bioinformatics skills of the data analysis scientist(s) assigned to support this study and their planned involvement in the project

The method section of the project plan must be detailed enough to allow evaluation of the technical feasibility. It must also be clearly stated that sufficient genetic material is available from the study subjects such that a range of sequencing technologies can be used in order to produce high quality genome assemblies.

Evaluation

The applications will be subject to peer review by an evaluation panel with international representation.

Successful applications should fulfil the following main criteria:

  • Scientific quality
  • Involvement of the applicant group particularly in the data analysis phase
  • Feasibility

Decisions

The final decision on funded projects in the first call will be made by the SciLifeLab National Board at its meeting November 12.