Examining molecular machines


Sebastian DeindlHe has long been intrigued by the notion that virtually all chemical reactions in our bodies are carried out by microscopic, yet intricate molecular machines. For this reason, he decided to study the workings of these machines at a molecular level.

Sebastian Deindl‘s research focuses on nucleic acid-interacting protein machines that regulate gene expression or directly alter the genetic information. By combining single-molecule fluorescence imaging techniques with structural and biochemical approaches, he aims at a molecular-level understanding of how the dynamics and structures of these protein machines enable their function and regulation.

− Unraveling these molecular mechanisms is directly relevant for human health. Many human disease states involve the aberrant activity or dysregulation of important protein machines, and understanding their molecular mechanisms can be an important first step towards developing therapeutic intervention strategies, said Sebastian Deindl.

He obtained his PhD from the University of California at Berkeley. There he studied the allosteric control of protein kinases and developed a passion for correlating protein structure with function. During his postdoctoral research at Harvard he examined the dynamics of chromatin remodeling enzymes using single-molecule fluorescence imaging techniques. He was recruited as a SciLifeLab Fellow at Uppsala University during 2014.

− What drives me to do research is a passion for science, in particular a deep curiosity to understand the workings of protein machines. Uncovering some of the molecular mechanisms that enable their function and regulation is truly exciting. SciLifeLab is an ideal place to carry out my research program due to the outstanding local expertise and infrastructure, excellent funding, and a great potential for collaborative research within SciLifeLab.

Short facts:

Name: Sebastian Deindl.

Profession: Assistant professor at the Department of Cell and Molecular Biology, Uppsala University.

Connection to SciLifeLab: SciLifeLab fellow at Uppsala University.

Leisure activities/hobbies: Traveling, hiking, skiing, and water sports such as surfing and windsurfing.

What you didn’t know about Sebastian Deindl: He is quite fond of learning new languages – he speaks English, German, French and Spanish, and is currently learning Swedish.

Research group

December 2014
Sara Engström