Our group is working to understand human immune system variation between individuals and within individuals over time. We are interested in the factors that determine this variation and in particularly their influence early in life as they imprint on the developing immune system and shape its composition and function for with long-term consequences. We are also interested in understanding how these phenomena relate to the risk of severe infections, malignancies and immune mediated diseases.
To understand systems-level behaviors in the human immune system, we develop and apply novel experimental and data analysis tools that allow for comprehensive analyses of blood samples using mass cytometry, cell sorting and sequencing-based approaches. By simultaneously analyzing all blood cell populations from different individuals over time, their frequencies and functional states, and combining such analyzes with plasma protein measurements, we are aiming for systems-level characterization of this system in order to understand its regulation.
By combining the immune system analyses with microbiome analyses, biometrics and individual exposure data, we are hoping to understand how various influences shape immunity in humans.
Petter Brodin is also Facility Director of Mass Cytometry.
Petter Brodin, M.D., Ph.D, assistant professor and resident in pediatrics
Anna-Karin Bernhardsson, Specialist nurse, Neonatology. Research nurse
Axel Olin, Msc Biomedical science, PhD-candidate
Christian Pou, PhD Molecular biology, postdoc
Dieudonne Nkulikiyiumfura, Msc Physics, PhD candidate
Jaromir Mikes, PhD, Senior scientist
Jun Wang, PhD Chemical physics, Lab engineer
Lakshmikanth Tadepally, PhD Immunology, Research coordinator
Yang Chen, PhD Information science, Senior data scientist
- Human immune system variation
Brodin P, Davis Mm
Nature reviews. Immunology 2017;17(1):21-29
- Immune Adaptation to Environmental Influence: The Case of NK Cells and HCMV
Rölle A, Brodin P
Trends in immunology 2016;37(3):233-43
- Powerful Populations Respond to Viruses and Vaccines
- Variation in the human immune system is largely driven by non-heritable influences
Brodin P, Jojic V, Gao T, Bhattacharya S, Angel Cj, Furman D, et al
- Automatic Classification of Cellular Expression by Nonlinear Stochastic Embedding (ACCENSE)
Shekhar K, Brodin P, Davis Mm, Chakraborty Ak
Proceedings of the National Academy of Sciences of the United States of America 2014;111(1):202-7