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Biomarkers and systems immunology


This research area aims at creating capabilities for discovery and validation of diagnostic, predictive, prognostic and therapeutic biomarkers. In addition, building capabilities for systems immunology and systems virologi of COVID-19 infected patients, as well as concepts towards individualized monitoring and targeting of cytokine storms are also part of the aim.

This area consists of 6 individual projects, all together funded by a total of 6,6 MSEK. Led by researchers at KTH Royal Institute of Technology, Karolinska Institutet, University of Gothenburg, Lund University and Linköping University. 

Coordinator: David Gotthold, KTH Royal Institute of Technology

Scientific lead: Jacob Odeberg, KTH Royal Institute of Technology, and Petter Brodin, Karolinska Institutet

Projects


Identification of plasma biomarkers for risk stratification of hospitalised Covid-19 patients
Jacob Odeberg, KTH

Prediction of severe disease in Covid-19
Lars-Magnus Andersson, University of Gothenburg      

Taking back the control of the SARS-CoV2 antiviral immune response as a mean to neutralize the COVID19 disease pathogenicity
Marie Larsson, Linköping University

Systems immunology analyses of the cytokine storm in COVID-19
Petter Brodin, Karolinska Institutet

Establishing a biobank of clinical specimens for studying evolution of viral diversity and development of immune response, including inflammation, seroprevalence and protective antibodies, in SARS-Cov2 infection (Research project)
Patrik Medstrand, Lund University  

Dynamics and longevity of the specific adaptive immune response in COVID-19 patients
Davide Angeletti, University of Gothenburg