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Host cell systems biology and targets


This research area aims at creating capabilities for discovery and functional understanding of the virus interactome and host effects, and build capabilities for high-throughput (chemical and CRISPR) analysis of virus-infected cells. Furthermore, the projects aim to build cell models, assays and data. 

This area consists of 11 individual projects, all together funded by a total of 5,3 MSEK. Led by researchers at Uppsala University, KTH Royal Institute of Technology, Karolinska Institutet, Lund University and Umeå University.

Coordinator: Marjo Puumalainen, Karolinska Institutet

Scientific lead: Oscar Fernandez-Capetillo and Päivi Östling, Karolinska Institutet

Projects


Functional characterization of Covid19-host response using single-cell transcriptomics and CRISPR screens
Anna Överby Wernstedt, Umeå University

Immediate molecular response to SARS-CoV-2 infection
Jonas Klingström, Karolinska Institutet

Mapping SARS-CoV-2 host-pathogen interactions for drug repurposing
Ylva Ivarsson, Uppsala University  

Viral-host interaction of SARS-CoV-2 protein corona
Maria Pernemalm, Karolinska Institutet      

Profiling of host proteins associated to the envelope of SARS-CoV-2
Claudia Fredolini, KTH

Genetic screens to identify novel determinants of SARS-CoV-2 infection
Oscar Fernandez-Capetillo, Karolinska Institutet    

CoronaCETSA
Leo Hanke, Karolinska Institutet    

Identification of host factors targeted by coronaviruses by Thermal proteome profiling
Oscar Fernandez-Capetillo, Karolinska Institutet    

High throughput imaging platform
Erdinc Sezgin, Karolinska Institutet                

Human precision cut lung slices as an ex vivo model for studying SARS-CoV2 infection and identifying potential therapies
Darcy Wagner, Lund University     

Cas13-CoV
Claudia Kutter, Karolinska Institutet