Viral sequence evolution
This research area aims at developing capabilities for viral genome sequencing of all positive patients to follow mutations and enable tracing of infection spread. The large-scale genome sequencing capability will also contribute to establishing a database of genome variation in collaboration with similar sequencing efforts such as the UK COVID-19 Sequencing Consortium.
This area consists of 4 individual projects, all together funded by a total of 1,7 MSEK. Led by researchers at Uppsala University, Karolinska Institutet, Stockholm University.
Coordinator: Alice Sollazzo, Uppsala University
Scientific lead: Ulf Gyllensten, Uppsala University
COVseq – Developing COVseq for mass-scale SARS-CoV-2 sequencing
Nicola Crosetto, Karolinska Institutet
A community resource for SARS-CoV-2 structure, interactome and evolution
Arne Elofsson, Stockholm University
Rapid cDNA and direct RNA sequencing of SARS-CoV-2 using Oxford Nanopore
Lars Feuk, Uppsala University
Analysis of essential genes and validity as drug targets
Tomas Nyman, Karolinska Institutet