Postdoctoral Fellow in Human Exposomics

Published: 2019-02-04


Stockholm University/SciLifeLab

Project description
We seek a postdoctoral fellow with strong mass spectrometry skills to develop new methods for exposomics in human biofluids. This will involve multiplexing of target methods for trace-contaminants in limited volumes of sample, and development of new workflows in nontarget mass spectrometry (GC- and LC-Orbitrap) to characterize complex environmental chemical mixtures in human serum or urine. The position is a two year postdoctoral fellowship fully funded by the Swedish Research Council, Formas. You will work in a larger team of toxicologists, molecular biologists and epidemiologists on a project with the overall goal to determine if paternal exposure to mixtures of environmental contaminants may affect offspring via epigenetic  inheritance. To this end, we have recently initiated a unique birth cohort in Sweden to test hypotheses about environmental exposures (exposome) and subsequent human development, health and disease.

Main responsibilities
The postdoctoral fellow will be supervised by Professors Jonathan Martin and Oskar Karlsson in the Exposure & Effects Unit, Department of ACES. The successful candidate will work primarily at Science for Life Laboratory (SciLifeLab) in the Ultratrace NonTarget Lab (UNTarget) where a major objective will be to establish analytical conditions, sample preparation, and data analysis workflows for comprehensive small molecule profiling and quantification in biofluids using HPLC- or GC-Orbitrap instruments. A combination of targeted analysis, suspect-screening and untargeted workflows are to be established. The candidate will need to develop sensitive methods with excellent quality control, interpret high resolution mass spectrometry data, conduct MS/MS experiments, and quantify or semi-quantify analytes in complex biofluid samples. The postdoctoral fellow will be expected to plan, conduct, interpret and communicate the research and results.

Qualification requirements
Postdoctoral positions are appointed primarily for purposes of research. Applicants are expected to hold a Swedish doctoral degree or an equivalent degree from another country prior to the start date.

Assessment criteria
The degree should have been completed no more than three years before the deadline for applications. An older degree may be acceptable under special circumstances, which may involve sick leave, parental leave, clinical attachment, elected positions in trade unions, or similar. In the appointment process, special attention will be given to research skills in mass spectrometry and analytical chemistry. Previous research experience in high resolution mass spectrometry, metabolomics or exposomics will be considered a great asset, as will the ability to interpret large mass spectrometry datasets using open software such as R or Python.

Terms of employment
The position involves full-time employment for a maximum of two years, with the possibility of extension under special circumstances. Start date is suggested as May 2019, but is flexible.

Contact
Further information about the position can be obtained from Professor Jonathan Martin, telephone: +46 72 146 27 73, jon.martin@aces.su.se.

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