Postdoctoral Fellow in Mixture Toxicology and High-Throughput Screening

Published: 2019-02-04


Stockholm University/SciLifeLab

Project description
We seek a postdoctoral fellow with strong skills in molecular toxicology, or in a closely related field, to develop and apply methods for High-Throughput Screening (HTS) and High Content Analysis (HCA), to estimate the health risks of real-world environmental chemical mixtures in cells. This will involve work with established cellular assays in HTS format and development of image-based HCA methods to elucidate the effects of environmental chemical mixtures found in individual human blood samples. The project will make effective use of existing national infrastructure, including liquid handling robotics and HTS technology, at Science for Life Laboratory (SciLifeLab). The position is a two year postdoctoral fellowship fully funded by the Swedish Research Council Formas. The successful candidate will work as part of a bigger team involving toxicologists, analytical chemists, molecular biologists and bioinformaticians to understand the toxicological effects of environmental chemical mixtures in the human body.

Main responsibilities
The postdoctoral fellow will be supervised by Professors Oskar Karlsson and Jonathan Martin in the Exposure & Effects Unit, Department of ACES. The successful candidate will work primarily at SciLifeLab (Solna). The major objective will be to establish state-of-the art cellular assays in HTS format and develop new image-based HCA assays to measure the cytotoxicity, epigenetic effects and endocrine disrupting potential of environmental chemical mixtures. The postdoctoral fellow will be expected to plan, conduct, interpret and communicate the research and results.

Qualification requirements
Postdoctoral positions are appointed primarily for purposes of research. Applicants are expected to hold a Swedish doctoral degree or an equivalent degree from another country prior to the start date.

Assessment criteria
The degree should have been completed no more than three years before the deadline for applications. An older degree may be acceptable under special circumstances, which may involve sick leave, parental leave, clinical attachment, elected positions in trade unions, or similar. In the appointment process, special attention will be given to research skills in molecular toxicology and cell culture work. Previous research experience in HTS, high content cell imaging and analysis will be considered a great asset, as will the ability to interpret large datasets using open software such as R or Python.

Terms of employment
The position involves full-time employment for a maximum of two years, with the possibility of extension under special circumstances. Start date is suggested as May 2019, but is flexible.

Contact
Further information about the position can be obtained from Associate Professor Oskar Karlsson, oskar.karlsson@aces.su.se or Professor Jonathan Martin,  telephone: +46 72 146 27 73, jon.martin@aces.su.se.

 

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