High-throughput and high-content serology

The research area aims at building capabilities for high-throughput serology diagnostics and national testing, as well as contributing to POC testing setup. Furthermore, understanding the nature of immune response, exploring infection epidemiology and neutralizing antibody development are crucial for this area. 

This area consists of 14 individual projects, funded a total of 11,9 MSEK. Led by researchers at KTH Royal Institute of Technology, Uppsala University, Karolinska Institutet, Stockholm University, Umeå University, University of Gothenburg and Lund University. 

Coordinator: Maria Pernemalm, Karolinska Institutet

Scientific lead: Janne Lehtiö, Karolinska Institutet

Projects

Optimized expression of the SARS-Cov-2 Spike protein in mammalian cells for serology testing and functional studies
Fredrik Sterky, University of Gothenburg

Production of SARS-CoV-2 surface proteins in HEK293 cells*
Juni Andréll, Stockholm University

Biological investigations of Covid-19 in cancer patients
Gunilla Enblad, Uppsala University

Peptides for serological test of COVID-19 antibodies and as molecular tools
Ulf Göransson, Uppsala University

Seroprevalence and predictors of COVID-19 disease severity in two areas of Sweden
Anne Lindberg, Umeå University

Large-scale production of a bio-safe antigen of COVID-19 and chimeric bat coronaviruses
Kenta Okamoto, Uppsala University

Translational serology for a population-wide assessment of Covid19 immunity
Jochen Schwenk, KTH

Multiplex analysis of immune response against Covid-19
Sophia Hober, KTH

Rapid development of novel antibody assays diagnosing Covid-19
Jan-Åke Liljeqvist, University of Gothenburg

Human antibodies against the SARS-CoV-2 spike protein
Mats Ohlin, Lund University

Characterization of the B cell response during SARS-CoV-2 infection
Karin Loré, Karolinska Institutet

PLA-based large-scale analysis of Corona virus immunity
Ulf Landegren, Uppsala University

Neutralizing human B-cell derived monoclonal antibodies to SARS-CoV-2
Pontus Nordenfelt, Lund University

SICoV – Serological Investigations on SARS-CoV-2 and other coronaviruses – improved diagnostics and knowledge
Åke Lundkvist, Uppsala University

Read more

Research area project descriptions
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