Registration for the meeting to be submitted by e-mail: firstname.lastname@example.org
before January 15, 2016
08:30 Welcome: Prof Per Artursson and Assoc Prof Christel Bergström
Session 1: Omics and Predictive Pharmacokinetics.
Chair: Prof Per Artursson, Uppsala University, Sweden
08:45 Quantitative Targeted Proteomics for ADME Predictions.
Prof Tetsuya Terasaki, Tohoku University, Japan
09:30 Quantification of ADME proteins: An inter-laboratory comparison.
Christine Wegler, Uppsala University, Sweden
09:50 Coffee break
10:30 Metabolomic and Genomic Studies Reveal New Roles for Membrane Transporters.
Honorary Doctor Lecture: Prof Kathleen Giacomini, University of California, San Francisco, USA
11:15 Challenges of disposition of therapeutic proteins – comparison to small molecules.
Dr Pawel Baranczewski, Uppsala University, Sweden
11:35 Size matters – Ussing chambers and modeling of human intestinal absorption of small molecules
Dr Patrik Lundqvist, Uppsala University, Sweden
Session 2: New technologies in drug discovery.
Chair: Dr Pawel Baranczewski, Uppsala University, Sweden
13:15 Further learnings on molecular complexity, obesity and accessibility.
Dr Michael Hann, Glaxo Smith Kline (GSK), Stevenage, UK
14:00 Microfluidics, microscopy and microbes – technologies for investigating single molecules in live
Dr Mats Walldén, Uppsala University, Sweden
14:25 Impact of intracellular unbound drug concentrations on drug effects.
André Mateus, Uppsala University, Sweden
14:45 Coffee break
Session 3: Drug delivery beyond the rule-of-5.
Chair: Assoc Prof Christel Bergström, Uppsala University, Sweden
15:30 Evolving a portfolio beyond the rule-of-5.
Dr Michael Hageman, Bristol Myers Squibb (BMS), Princeton, USA
16:15 Early prediction of drug loading in lipid-based formulations.
Linda Alskär, Uppsala University, Sweden
16:35 Molecular dynamics simulations of drug solubility in intestinal fluids and lipid-based formulations.
Dr Per Larsson, Uppsala University, Sweden
16:55 Concluding remarks.
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