Stanford University, USA
Medicine is no longer a one-size-fits-all system, and is quickly becoming personalized, predictive, and participative. To meet these changing needs, my lab develops and applies novel technologies for measuring and modifying biological systems across scales. With precision genome editing, we have measured the effects of perturbations in isolation to better understand their phenotypic consequences. In the context of rare genetic diseases, this has allowed us to identify a novel therapeutic strategy for patients genetically-predisposed to cardiomyopathy. To complement these genetic approaches, we have developed wearable multi-parametric biosensors and novel measurement devices, including a magnetic levitation device that is a low-cost, high-throughput solution for characterizing circulating tumor cells. Our MagLev device has successfully been applied towards detecting drug resistance, as well as resolving cells and molecules in bodily fluids/tissues. These technological breakthroughs will help build the high-precision and wellness-focused medicine of the future.
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