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DTSTART;TZID=Europe/Stockholm:20260424T090000
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SUMMARY:Clinical and translational analyses in the neoadjuvant PREDIX trials in breast cancer
DESCRIPTION:Speaker\n\n\n\nTheodoros Foukakis\, Karolinska Institutet \n\n\n\n\n\n\n\n \n\n\n\n \n\n\n\nAbstract\n\n\n\nThe PREDIX trials are academic\, randomised phase 2 studies of neoadjuvant therapy in breast cancer\, coordinated by Karolinska. Patients with luminal breast cancer were randomised to either chemotherapy or endocrine therapy in combination with palbociclib. Patients with HER2-positive disease received preoperatively either a standard of care combination of chemotherapy and HER2-targeting antibodies or the antibody-drug conjugate trastuzumab-emtansine. Both trials had a translational focus with serial biopsies and blood samples collected at baseline and during treatment. A comprehensive multimodal profiling of the tumours has been carried out\, and the molecular profiles of the tumours have been correlated to the clinical outcomes. The initial results from these studies will be presented. \n\n\n\nShort biography\n\n\n\nTheodoros Foukakis\, MD\, PhD\, is Professor of Oncology at Karolinska Institutet and a senior attending physician and scientific head for breast cancer at the Comprehensive Cancer Centre\, Karolinska University Hospital\, Stockholm\, Sweden. He is head of the national guidelines group for breast cancer in Sweden\, a member of the Swedish Breast Cancer Group (SweBCG)\, and a steering committee member of The Early Breast Cancer Trialists’ Collaborative Group (EBCTCG). \n\n\n\nDr Foukakis completed his medical studies at the University of Crete\, Greece\, in 2002 and moved to Stockholm\, Sweden\, where he pursued a PhD in cancer genetics at Karolinska Institutet. Subsequently\, he undertook clinical training in Oncology at Karolinska University Hospital between 2005 and 2009 and has since worked as a specialist\, combining clinical work with research\, with a focus on breast cancer. \n\n\n\nHe has led several investigator-initiated trials sponsored by Karolinska University Hospital and served as national principal investigator for many industry-sponsored trials from phase 1 to phase 3. \n\n\n\nHe leads a research group of 22 members and has secured independent funding through national or international competitions over the last 10 years. His group is particularly interested in drug and biomarker development in breast cancer with a focus on multi-omics analyses and machine learning. \n\n\n\nAbout Clinical Talk:\n\n\n\nAfter seven successful seasons and over seventy dedicated speakers\, we are excited to continue showcasing the contributions of our diverse clinical\, academic\, and industry life science community. This season will feature ten insightful talks following our well-established format. \n\n\n\nThe overarching theme is “How to Achieve Feasible Implementation.” Sessions will be held monthly on Fridays from 09:00 a.m. to 10:00 a.m. via Zoom\, with occasional exceptions. Each talk will be followed by an engaging Q&A session\, moderated by the standing host\, Rikard Fred\, and a guest moderator with subject-matter expertise to enrich the discussion. \n\n\n\nIn today’s post-pandemic world\, let’s explore how academic\, clinical\, and industry research\, together with technological advances\, can drive practical\, sustainable solutions. Join us for an opportunity to gain fresh insights\, expand your knowledge\, and connect with experts shaping the future of life sciences! \n\n\n\nClinical talks are organised by SciLifeLab.
URL:https://www.scilifelab.se/event/clinical-talk-clinical-and-translational-analyses-in-the-neoadjuvant-predix-trials-in-breast-cancer-biological-insights-and-clinical-implications/
LOCATION:Online event via Zoom
CATEGORIES:Event
ORGANIZER;CN="Clinical Talks":MAILTO:precisionmedicine@scilifelab.se
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