BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//SciLifeLab - ECPv6.15.18//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:SciLifeLab
X-ORIGINAL-URL:https://www.scilifelab.se
X-WR-CALDESC:Events for SciLifeLab
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:Europe/Stockholm
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20210328T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20211031T010000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20220327T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20221030T010000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20230326T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20231029T010000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20220511T140000
DTEND;TZID=Europe/Stockholm:20220511T153000
DTSTAMP:20260404T082705
CREATED:20220426T132422Z
LAST-MODIFIED:20220507T113616Z
UID:67956-1652277600-1652283000@www.scilifelab.se
SUMMARY:Decoding the development of the human spinal cord by multi-omics
DESCRIPTION:Decoding the development of the human spinal cord by multi-omics \n\n\n\nXiaofei Li and Erik Sundström \n\n\n\nHDCA Seminar Series 2022 | Spinal cord \n\n\n\nThe human spinal cord has highly diverse cell types\, which are generated during development\, governed by a series of temporal and spatial events for proper spinal cord assembly and function. However\, the molecular regulation of cell fate specification in the human developing spinal cord remains largely unknown. Here\, by performing single-cell RNA sequencing\, spatial transcriptomics and in situ sequencing\, we integrate the datasets and provide a comprehensive single-cell and spatial transcriptomic atlas of the developing human spinal cord of the first trimester\, from postconceptional week 5 to 12. We observe that all major cell populations in human adult spinal cord have been specified within the first trimester with abundant cell states\, and identify the key genes associated with cell fate choices and their spatial expression. Unexpectedly\, we find that during early cell fate specification\, many human neural progenitor cells have lost their self-renewal capacity. Further the the expression of gliogensis genes is much higher in human compared to the correspondent rodents at the early stage\, suggesting earlier gliogenesis in human. Finally\, we demonstrate how to use our developmental map for molecular cues that direct sequential cellular differentiation and define cells and locations associated to both normal development and spinal cord diseases. \n\n\n\nsign up to attend\n\n\n\nPlease register also if you want to participate in the digital broadcast. The Zoom link will be sent out through the registration system.  \n\n\n\n– \n\n\n\nHuman developmental cell atlas (HDCA) is the Swedish effort within the human cell atlas (HCA)\, one of the largest international scientific projects. The project aim is to create a comprehensive molecular atlas of human prenatal development at the molecular resolution using state-of-the-art multi-omic technologies such as single-cell RNA-seq\, Spatial Transcriptomics\, in situ sequencing in order to provide deeper insight into how variations and deviations contribute to health and disease. \n\n\n\nThe HDCA Seminar Series 2022 invites you to join us on a journey of early human organogenesis of several organs at the single-cell and spatial resolution. Seminars will be held at SciLifeLab Gamma building on Wednesdays at 14:00 or 15:00 and also via Zoom. After each seminar\, we will have up to 30 min round up discussions with the speaker on how you can contribute to the atlas! \n\n\n\nWarm Welcome!
URL:https://www.scilifelab.se/event/decoding-the-development-of-the-human-spinal-cord-by-multi-omics/
LOCATION:Gamma 2 Lunchroom\, SciLifeLab\, Tomtebodavägen 23\, Solna\, Sweden
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/04/hdca_logo.png
ORGANIZER;CN="The Human Developmental Cell Atlas":MAILTO:hdca-sweden@scilifelab.se
END:VEVENT
END:VCALENDAR