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DTSTART;TZID=Europe/Stockholm:20220411T151500
DTEND;TZID=Europe/Stockholm:20220411T161500
DTSTAMP:20260408T014102
CREATED:20220315T160745Z
LAST-MODIFIED:20220404T080634Z
UID:63447-1649690100-1649693700@www.scilifelab.se
SUMMARY:Decreased levels of oxygen radicals cause autoimmune disease.
DESCRIPTION:Prof. Rikard Holmdahl \n\n\n\nKarolinska Institute\, Sweden \n\n\n\nRegister HERE\n\n\n\nRikard Holmdahl made his PhD (1985) and MD (1987) at Uppsala University. Professor in medical inflammation research Lund University 93-07. Professor at Karolinska Institute from 2008 \n\n\n\n\n\n\n\nVenue: Hybrid meeting – Trippelrummet\, Navet and zoom \n\n\n\n\n\n\n\n\n\n \n\n\n\nTitle of the seminar: Finding and understanding genes associated with common diseases; decreased levels of oxygen radicals cause autoimmune disease\n\n\n\nA long-standing challenge is to understand which genes that cause common complex diseases\, such as rheumatoid arthritis\, atherosclerosis or cancer\, and thereby understand the disease causes. However\, even though we know the human sequence and can genotype millions of individuals it is very difficult to conclusively identify the single nucleotide variants that cause the diseases. We have taken another approach through animal models. Both genetics and diseases show similarities with humans\, and we have shown that it is possible to not only identify the loci associated with disease but also exactly position the polymorphic nucleotides for common autoimmune diseases such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE).  \n\n\n\nI will focus on the first gene that we cloned\, Ncf1\, which regulate immune tolerance through different levels of oxygen radicals\, or more precisely hydrogen peroxide. It is the major gene causing SLE and is important in Sjögren’s syndrome and RA and most likely most autoimmune disease. \n\n\n\nTo understand the role of Ncf1 is also complicated as peroxide seem to regulate many different pathways leading to autoimmune diseases. I will discuss how we think it regulates RA and SLE but also how it could explain our normal behaviour\, thus explaining why Ncf1 variants are common in both rat and human population. \n\n\n\nRead more about ikard Holmdahl´s research http://ki.se/en/mbb/research-division-of-medical-inflammation-research
URL:https://www.scilifelab.se/event/decreased-levels-of-oxygen-radicals-cause-autoimmune-disease/
LOCATION:Navet\, SciLifeLab Uppsala\, SciLifeLab Uppsala\, BMC C11\, Husargatan 3\, Uppsala\, 75237\, Sweden
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png
ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
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