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DTSTART;TZID=Europe/Stockholm:20220427T140000
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SUMMARY:Developmental origins of cell heterogeneity in the human lung
DESCRIPTION:HDCA Seminar Series 2022 | Lung \nChristo Samakovlis and Alexandros Sountoulidis \nThe lung contains numerous specialized cell-types with distinct roles in tissue function and integrity. To clarify the origins and mechanisms generating cell heterogeneity\, we created a first comprehensive topographic atlas of early human lung development. We report 83 cell states\, several spatially-resolved developmental trajectories and predict cell interactions within defined tissue niches. We integrated scRNA-Seq and spatial transcriptomics into a web-based\, open platform for interactive exploration. To illustrate the utility of our approach we show distinct states of secretory and neuroendocrine cells\, largely overlapping with the programs activated either during lung fibrosis or small cell lung cancer progression. We define the origin of uncharacterized airway fibroblasts associated with airway smooth muscle in bronchovascular bundles\, and describe a trajectory of Schwann cell progenitors to intrinsic parasympathetic neurons controlling bronchoconstriction. Our atlas provides a rich resource for further research and a reference for defining deviations from homeostatic and repair mechanisms leading to pulmonary diseases. \n  \n– \nHuman developmental cell atlas (HDCA) is the Swedish effort within the human cell atlas (HCA)\, one of the largest international scientific projects. The project aim is to create a comprehensive molecular atlas of human prenatal development at the molecular resolution using state-of-the-art multi-omic technologies such as single-cell RNA-seq\, Spatial Transcriptomics\, in situ sequencing in order to provide deeper insight into how variations and deviations contribute to health and disease. \nThe HDCA Seminar Series 2022 invites you to join us on a journey of early human organogenesis of several organs at the single-cell and spatial resolution. Seminars will be held at SciLifeLab Gamma building on Wednesdays at 14:00 or 15:00 and also via Zoom. After each seminar\, we will have up to 30 min round up discussions with the speaker on how you can contribute to the atlas!  \nWarm Welcome! \n  \n\n\nregistration
URL:https://www.scilifelab.se/event/developmental-origins-of-cell-heterogeneity-in-the-human-lung/
LOCATION:Gamma 2 Lunchroom\, SciLifeLab\, Tomtebodavägen 23\, Solna\, Sweden
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/04/logo_hdca2.png
ORGANIZER;CN="The Human Developmental Cell Atlas":MAILTO:hdca-sweden@scilifelab.se
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