Venue: Navet Mötestorget, BMC Uppsala universitet
Bile salt-stimulated lipase (BSSL) was first discovered as a lipolytic enzyme secreted from the lactating mammary gland in some species and with all characteristics needed to contribute significantly to the digestion of milk lipids in the upper small intestine. Surprisingly, more recently we found that BSSL is also a hitherto unrecognized player in inflammation. This conclusion was based on the observations that patients suffering from rheumatoid arthritis (RA) have increased levels of BSSL in serum and that BSSL knockout mice in arthritis models are protected from developing disease. Further support came from studies showing that similar protection could be obtained by treatment with anti-BSSL antibodies, which opened the possibility for a novel biological drug for treatment of inflammatory diseases, primarily juvenile idiopathic arthritis and RA. This initiated an indispensable and fruitful collaboration with SciLifeLab Drug Discovery and Development platform to develop a human anti-BSSL antibody, a work that has been completed and a candidate drug directed towards a unique target is now under production.
Professor Olle Hernell and Assoc. Professor Susanne Lindquist, Umeå University
Short speaker biographies:
Olle Hernell is professor emeritus in pediatrics and former head of Pediatrics at the department of Clinical Sciences, University of Umeå, Sweden. He is former chair of the Swedish Expert Committee on Pediatric Nutrition (PENUT) and the Swedish Royal Academy of Sciences´ National Committee for Nutrition and Food Sciences. Prof. Hernell´s research interest has been within pediatric nutrition, spanning from basic science to clinical trials with particular focus on bioactive substances in human milk, fat digestion and absorption in the newborn, iron requirement in infants and children, celiac disease, and more recently, the role of the Bile Salt-Stimulated Lipase in inflammation. He is one of the founders of Lipum AB and now CMO and member of the board.
Susanne Lindquist is a molecular biologist and associate professor at the department of Odontology/Molecular Periodontology, Umeå University, Sweden. She received her Ph D degree at the department of Microbiology, Umeå University in 1992. Her interest in the Bile Salt-Stimulated Lipase and its role in inflammation began in the late 90th when she was a postdoc in the lab of prof. Olle Hernell. Susanne Lindquist is CSO and one the founders of Lipum AB.
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