The main goal of EpiChrom 2017 is to provide common grounds for meeting, networking and establishing collaboration among researchers in Sweden studying epigenetics and chromatin. Epigenetics has proven important in defining cell identity and dysregulation of epigenetic mechanisms is associated with disease. The field studies chromatin, non-coding RNA, transcription factors and DNA modifications, among others, and their consequences on the transcriptome. Epigenetics is one of the youngest fields in Life Sciences and in recent years has witnessed an unprecedented growth. As the field is a highly interdisciplinary, EpiChrom 2017 welcomes presentation of research spanning from molecular biology, to medicine, to bioinformatics and mathematics.
Registration is closed, as the room is now full.
For questions regarding the registration, please contact elina.staaf@scilifelab.uu.se
Rudbecksalen, Rudbeck Laboratory, Dag Hammarskjölds väg 20, Uppsala
| 08:00 | Registration and coffee |
| 08:30 | Welcome address |
| 08:40 – 10:00 |
Session I: Understanding Epigenetics I 8:40 Understanding the nexus between lncRNAs and chromatin-level gene expression 9:20 A microarray screen identifies novel TGFbeta-regulated long non-coding RNAs 9:40 The Chromatin remodeling complex B-WICH is required for DNA Pol I transcription activation by glucose stimulation |
| 10:00 | Coffee and sandwiches |
| 10:30 – 11:30 |
Session II: Epigenetics in solid tumors 10:30 Tissue-type specific functional annotation of transcription factor motifs for prioritization of noncoding variants 10:50 Exosomes released by pediatric glioma stem cells induce gene expression changes in neural cells 11:10 Orthotopic transplantation of pediatric glioma stem cells in mice mirrors the clinical course of the patient |
| 11:30 | Coffee break |
| 11:50 – 13:10 |
Session III: Epigenetics in hematological malignancies 11:50 A distinct gene regulatory network, established independent of coding mutations, underpins the CLL phenotype 12:10 Discovery of new molecular subgroups in pediatric ALL using DNA methylation classification and RNA-sequencing 12:30 Genome-wide DNA methylation profiling in chronic lymphocytic leukemia patients carrying stereotyped B-cell receptors 12:50 Epigenetic co-regulation as a potential therapeutic target in multiple myeloma |
| 13:10 | Lunch and posters |
| 14:15 | KEYNOTE LECTURE: Immune memory Henk Stunnenberg, Radboud Institute for Molecular Life Sciences (RIMLS), Nijmegen, The Netherlands |
| 15:15 | Coffee and sweets |
| 15:50 – 17:10 |
Session IV: Epigenetics and immunity 15:50 Reactivation potential of HIV-1 in primary CD4 T cells depend on the chromatin microenvironment 16:10 Major transcriptional changes observed in the Fulani, an ethnic group less susceptible to malaria 16:30 Enhancer regulation by GPS2 modulates macrophage inflammation 16:50 Utilizing epigenomics to understand neurodegeneration in Multiple Sclerosis: what are the neurons telling us? |
| 17:10 | Mingle |
| 08:30 – 10:10 |
Session V: Understanding Epigenetics II 8:30 Deciphering the cooperativity of Polycomb repression 9:10 Targeting Polycomb repressive complexes through evolutionary conserved DNA elements 9:40 Developmental patterning and gene regulation by the BEN-solo family 9:50 The future of epigenetics at SciLifeLab? |
| 10:10 | Coffee and sandwiches |
| 10:40 – 12:00 |
Session VI: Epigenetics across species 10:40 Ectopic application of H3K9me2 establishes postzygotic reproductive isolation in Arabidopsis 11:00 Imprinted gene regulation by the paternally expressed gene PHERES1 in Arabidopsis 11:20 Genetic dissection of Drosophila HDAC3 function 11:40 C12D8.1: A negative regulator of RNAi inheritance in Caenorhabditis elegans |
| 12:00 | Lunch and posters |
| 13:00 | KEYNOTE LECTURE: Computational Epigenomic Approaches for Deciphering the Non-coding Human Genome Jason Ernst, University of California, Los Angeles (UCLA), USA |
| 14:00 | Coffee break |
| 14:20 – 15:40 |
Session VII: Epigenomics 14:20 Mechanistic Insights into Autoinhibition of the Oncogenic Chromatin Remodeler ALC1 14:40 Identification of oligodendrocyte lineage states with single-cell ATAC-seq 15:00 Protein-coding sequence exclusion by alternative transcription start site usage across the human body 15:20 Nascent transcription plasticity in mouse embryonic stem cells |
| 15:40 | Coffee and sweets |
| 16:10 – 17:20 |
Session VIII: Epitools 16:10 Chromatrap®; A more efficient, sensitive & robust method of chromatin immunoprecipitation (commercial) 16:25 Active Motif, enables chromatin and gene regulation research (commercial) 16:40 A novel methodology for identifying genome-wide RNA-chromatin interactions 17:00 Modelling the dynamics of epigenetic memory |
| 17:20 | Closing remarks |
Presentations must be loaded onto the presentation computer in advance: either before the first lecture, or during the lunch or coffee breaks.
Posters are to be hung during the morning the same day as your poster session.
Nordic Diagnostica / Chromatrap
Antonia Kalushkova*, Postdoctoral Fellow, SciLifeLab, Uppsala University (IGP)
Klev Diamanti, PhD student, SciLifeLab, Uppsala University (ICM)
Helena Jernberg-Wiklund, Professor, SciLifeLab, Uppsala University (IGP)
Jan Komorowski, Professor, SciLifeLab, Uppsala University (ICM)
*Contact the committee via: antonia.kalushkova@igp.uu.se
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