BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//SciLifeLab - ECPv6.17.2//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:SciLifeLab
X-ORIGINAL-URL:https://www.scilifelab.se
X-WR-CALDESC:Events for SciLifeLab
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:Europe/Stockholm
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20250330T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20251026T010000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20260329T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20261025T010000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20270328T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20271031T010000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20260825T151500
DTEND;TZID=Europe/Stockholm:20260825T161500
DTSTAMP:20260817T131510Z
CREATED:20260817T123116Z
LAST-MODIFIED:20260817T131510Z
UID:200657-1787670900-1787674500@www.scilifelab.se
SUMMARY:Lipid regulation of TRP channels: More than meets the eye
DESCRIPTION:For the fall’s first Spotlight seminar\, we are happy to welcome Professor Ute Hellmich from the Faculty of Chemistry and Earth Sciences\, Institute of Organic Chemistry and Macromolecular Chemistry (IOMC) at Friedrich-Schiller-Universität Jena \n\n\n\nAbstract\n\n\n\nCells rely on membrane receptors to detect and integrate diverse environmental signals. Ligands such as small molecules\, peptides or ions trigger conformational changes that regulate downstream signalling cascades. This classic\, 3D-centric view is challenged by the finding that nearly half of the human proteome is predicted to be intrinsically disordered. \n\n\n\nMany membrane receptors\, including most Transient Receptor Potential (TRP) channels\, contain large intrinsically disordered regions (IDRs) whose dynamic nature has severely hampered structural characterization. Therefore\, the contribution of IDRs to signal sensing remains poorly understood and the structural dimensions of TRP channels are notoriously underestimated. \n\n\n\nHere\, using an integrated structural biology approach\, we show that disordered channel regions contribute to multipartite signalling networks of plasma membrane and lysosomal TRP ion channels and play crucial roles in lipid-dependent functional regulation. This work thus provides a conceptual blueprint how complex membrane receptors are regulated by 
URL:https://www.scilifelab.se/event/lipid-regulation-of-trp-channels-more-than-meets-the-eye/
LOCATION:Gamma 2 Lunchroom\, SciLifeLab\, Tomtebodavägen 23\, Solna\, Sweden
CATEGORIES:Event
ATTACH;FMTTYPE=image/jpeg:https://www.scilifelab.se/wp-content/uploads/2023/10/Campus-solna-seminar-picture.jpg
ORGANIZER;CN="Spotlight Seminar Series":MAILTO:events@scilifelab.se
END:VEVENT
END:VCALENDAR