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SUMMARY:NGI and Affinity Proteomics seminar
DESCRIPTION:Next-generation affinity proteomics – inspiration for analysis and validation at SciLifeLab\n\n\n\nThe proteome refers to the entire set of proteins produced by all genes in the body\, and it is both dynamic and highly personalized. A protein biomarker indicates a change in expression or its state that correlates with the risk or progression of a disease\, or with the susceptibility of a disease to a given treatment. Such unique biomarkers are often found in low concentrations in plasma. The Proximity Extension Assay (PEA) commercialized by Olink Proteomics is one of the technologies developed to quantify plasma biomarkers from a range of concentrations and offers a high-throughput alternative to traditional methods\, such as ELISA.  \n\n\n\nThe newly released Olink Explore technology brings together the specificity of PEA with a high throughput Next Generation Sequencing (NGS) readout\, which today enables multiplex analysis of >3000 proteins from only a few microliters of body fluid. This technique is now available to researchers in Sweden via a collaboration between Affinity Proteomics and the National Genomics Infrastructure (NGI) at the SciLifeLab Explore Lab\, physically located at BMC in Uppsala. During the seminar we will briefly present the Olink Explore technology and data from users to give guidance and inspiration for future projects. \n\n\n\nThe seminar will be recorded and can be found at the SciLifeLab YouTube channel about 2 days after the event. \n\n\n\nThe Zoom link will be provided in the confirmation email. \n\n\n\nFor more information\, please contact explorelab@scilifelab.uu.se \n\n\n\nRegistration\n\n\n\nProgram\n\n\n\n15:00Welcome and introductionMikael Åberg\, Head\, Affinity Proteomics UppsalaJessica Nordlund\, Facility Director\, NGI Uppsala (moderator)15:05Olink Explore: Broader\, faster and more comprehensive proteomicsNikolaos Tertipis\, Olink Proteomics15:15Strategies for validating biomarkers in biofluids Claudia Fredolini\, Head\, Affinity Proteomics Stockholm15:25Experiences from a pilot study with Olink Explore in two ovarian cancer cohorts Stefan Enroth\, associate professor\, Uppsala University15:45Multiplatform approach for plasma proteomics in health and disease Fredrik Edfors\, Senior Researcher\, Karolinska Institutet16:05Disease-associated module enrichment and preanalytical considerations for robust biomarker discoverySandra Hellberg\, Postdoktor\, Linköping University& Ingrid Skelton Kockum\, Professor\, Karolinska Institutet16:25Q&AAll presenters16:45Closing remarksJessica Nordlund and Mikael Åberg17:00End of day
URL:https://www.scilifelab.se/event/ngi-and-affinity-proteomics-seminar/
LOCATION:Online event via Zoom
CATEGORIES:Event
ORGANIZER;CN="Affinity Proteomics":MAILTO:affinity.proteomics-uppsala@scilifelab.uu.se
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