October 10-11 2019, Biomedicum lecture theatre, Karolinska Institutet, Stockholm

The 2nd CryoNet Annual Symposium will highlight the latest discoveries in protein-nucleic acid complexes along with a view to the future of cryo-EM. Alongside presentations on important biological results will be exciting methodological advances emphasizing that cryo-EM is still in a major growth phase.

Students and postdocs are encouraged to apply to give talks and poster presentations

CryoNet is funded by the Knut and Alice Wallenberg Foundation and the Novo Nordisk Foundation.

Preliminary program

October 10: Hot structures

09.30-10.05 John Rubinstein, University of Toronto – Proton pumping V-type ATPases

10.05-10.25 Alexander Muhleip, Stockholm University – Structure of a mitochondrial ATP synthase

10.25-10.45 Ben Falcon, MRC Laboratory of Molecular Biology – Conformers of assembled Tau in human neurodegenerative diseases

10.45-11.00 Coffee

11.00-11.35 Kelly Nguyen, MRC Laboratory of Molecular Biology – Replenishing the ends: structural mechanism of human telomerase

11.35-11.55 Simone Cavadini, Friedrich Miescher Institute – DNA damage detection in nucleosomes involves DNA register shifting

12.00-13.30 Lunch + posters

13.30-14.05 Sarah Butcher, University of Helsinki – Antivirals –a new approach to an old problem

14.05-14.25 Anna Munke, Uppsala University – Structure of a marine algae virus, and the evolution of Picornaviridae viruses

14.25-14.45 Pavel Plevka, Masaryk University – Structure and genome ejection mechanism of S. aureus phage P68

14.45-15.10 Coffee

15.10-15.45 Lars-Anders Carlson, Umeå University – In situ studies of positive-sense RNA virus replication with cryo-ET

15.45-16.20 Ana Casanal, MRC Laboratory of Molecular Biology – Towards a molecular understanding of the eukaryotic mRNA 3’-end processing machinery

16.20-16.55 Clemens Plaschka, Research Institute of Molecular Pathology – Structural studies of nuclear pre-mRNA splicing

October 11: New methods

09.30-10.05 John Briggs, MRC Laboratory of Molecular Biology – Studying enveloped virus structure using subtomogram averaging

10.05-10.25 Ahmad Jomaa, ETH Zurich – Cryo-EM reveals the mechanism of SecA-mediated co-translational targeting of membrane proteins in bacteria

10.25-10.45 Jana Skerlova, Stockholm University – Structure of the minimal progenitor toxin complex of botulinum neurotoxin X

10.45-11.00 Coffee

11.00-11.35 Julia Mahamid, European Molecular Biology Laboratory – From translational stress response in eukaryotes to transcription-translation coupling in bacteria: Unique insights from in-cell cryo-electron tomography

11.35-11.55 Maxim Armstrong, University of California, Berkeley – Micro-scale fluid behavior during cryo-EM sample blotting

12.00-13.30 Lunch + posters

13.30-14.05 Johanna Höög, University of Gothenburg –  TAILS of a human sperm

14.05-14.25 Urška Rovšnik, Stockholm University – Characterizing functional states of a model ligand-gated ion channel by cryo-EM

14.25-14.45 Andrii Iudin, EMBL-EBI – EMPIAR: recent developments and outlook

14.45-15.10 Coffee

15.10-15.45 Elizabeth Wright, University of Wisconsin–Madison – Using Cryo-Electron Tomography to Study Host-Pathogen Interactions

15.45-16.20 Sharon Wolf, Weizmann Institute of Science – Chemical and Structural Insights with CryoSTEM tomography

16.20-16.55 Peijun Zhang, University of Oxford – Imaging virus assemblies in situ with cryo-EM

Organizers: Alexey Amunts, Bridget Carragher, Ausra Domanska, Gunnar von Heijne

Registration

Registration is now closed. Please submit late enquiries to the organizers – vasileios.kyriakidis@localhost.