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DTSTART;TZID=Europe/Stockholm:20260521T150000
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UID:198922-1779375600-1779379200@www.scilifelab.se
SUMMARY:Precision Oral Care Through Genomic Dentistry
DESCRIPTION:Clinical Genomics Webinar Series\n\n\n\nClinical Genomics Umeå is hosting this webinar as part of the Clinical Genomics Platform webinar series \n\n\n\nRedefining Chronic Disease Through Genomics and Multi-Omics: Insights from Dental Caries and Precision Dentistry \n\n\n\n\nJoin us on Zoom\n\n\n\n\n \n\n\n\nThis seminar will present a translational framework integrating clinical cohorts\, genomics\, and multi-omics to redefine dental caries as a biologically stratified disease.Three prospective studies will be highlighted: a birth cohort (mother–father–child)\, an adolescent case–referent cohort with 5-year longitudinal follow-up\, and an intervention study (n≈500 each).The genomic strategy integrates host and microbial variation to resolve distinct disease pathways. Host stratification based on PRH1\, PRH2\, and DMBT1–CNV identifies discrete 2- and 3-gene susceptibility profiles that quantitatively predict caries progression. In parallel\, genomic variation in surface adhesins and housekeeping genes of Streptococcus mutans reveals high-virulence strains capable of driving disease in genetically non-susceptible individuals\, demonstrating independent microbial risk trajectories.Multi-omics analyses\, including inflammatory profiling (Olink) and metabolomics of short-chain fatty acids (LC–MS)\, further define the 3-gene susceptibility profile as a distinct inflammatory caries type.Together\, these findings support a shift from descriptive to mechanism-based risk assessment\, establishing biologically defined risk groups with predictive value for disease progression. This provides a foundation for precision dentistry through targeted\, cost-effective prevention. The seminar will also address key challenges in validating and implementing host–microbe signatures in clinical practice. \n\n\n\nEveryone is welcome so feel free to spread the details with anyone who may be interested. Hope to see you there! \n\n\n\nHost: Linda Köhn\, Head of Unit\, Clinical Genomics Umeå \n\n\n\nInvited speaker: Nicklas StrömbergDepartment of Odontology\, Faculty of Medicine\, Umeå University
URL:https://www.scilifelab.se/event/precision-oral-care-through-genomic-dentistry/
LOCATION:Online event via Zoom
CATEGORIES:Event
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