We would like to invite you to a virtual Seminar on Wednesday, Oct 7th at 15.00, covering proximity ligation in genome assembly, comparative genomics, and phasing.
Wednesday, Oct 7th at 15.00: Restriction-enzyme free Hi-C (Omni-C) in Assembly and comparative Genomics
Omni-C: Restriction-enzyme free Hi-C in Genome Assembly and Comparative Genomics.
by Kai Kleiber, Ph.D. (Scientific Affairs at Dovetail).
Restriction Enzyme (RE)-based Hi-C is blind to approximately 20% of mappable genomes due to low RE site density. Here we introduce Omni-C™ technology, a sequence-independent endonuclease-based proximity-ligation assay that addresses the limitations of RE-based Hi-C approaches.
This Seminar will highlight that Omni-C™ libraries uniquely contain proximity-ligation characteristics with the advantage of uniform genome-wide coverage. This expanded data type enables not only improved Genome Assemblies but also applications relying on coverage uniformity, such as Structural Variation detection, SNP calling, and phasing.
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