How to get conclusive data from in vivo pharmacology studies? The role of ADME and pharmacokinetics.
09.30 Arrival & coffee
Chair: Prof Per Arvidsson, SciLifeLab DDD, Karolinska Institutet, Sweden
Prof Per Arvidsson, SciLifeLab DDD, Karolinska Institutet, Sweden
10:05 Integration of pharmacokinetics (PK) and pharmacodynamics (PD) in drug discovery
Prof Johan Gabrielsson, SLU, Sweden
11:00 Exposure in animal models – Maximizing value of ADME in vitro data
Dr Carl Pettersson, DMPK NCE Senior Designer, Merck-Soreno, Germany
Chair: Assoc Prof Kristian Sandberg, Uppsala University, Sweden
13:00 Using PK/PD modelling and standard ADME in vitro screens to predict therapeutic dosing in man: a case study
Dr Markus Fridén, Section Head, Modelling and Simulation, RIA iMed DMPK, Astra Zeneca
13:40 PK-PD disconnect and in vivo PD models in drug discovery
Prof Stephan Hjorth, PharmaLot Consulting AB, Sweden
14:20 Final conclusions
Assoc Prof Kristian Sandberg, Uppsala University, Sweden
14:30 Coffee break and discussion
Venue: Trippelrummet (E10:1307-E10:1309), SciLifeLab facilities Navet, Husargatan 3, Uppsala
Registration: Please register here.
Free bus shuttle: Bus transportation from/to SciLifeLab in Solna will be arranged:
Departure from Tomtebodavägen 23A, Solna at 08.00
Departure from Husargatan 3, Uppsala at 15.30
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