Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Austria
Andrea (Andi) Pauli obtained her PhD in Kim Nasmyth’s lab at Oxford University, UK, where she provided the first direct evidence that the protein-complex cohesin has essential non-mitotic functions. For her postdoc, Andi joined Alex Schier’s lab at Harvard University, USA.While her original goal was to identify functional lncRNAs during zebrafish embryogenesis, Andi’s research led to two key discoveries that have shaped her research since: first, translation is widespread outside of protein-coding regions; and second, these newly discovered translated regions can encode functionally important short proteins. In September 2015, Andi established her own lab at the Institute of Molecular Pathology (IMP) in Vienna, Austria, where she focuses on identifying new essential regulators during the germline-to-embryo transition.
Many transcripts have recently been found to contain short translated open reading frames that had been missed in previous gene annotations. A main focus of the Pauli lab is the identification of novel functional short proteins, using zebrafish as a model system. The Pauli lab has discovered two essential short proteins which differ in their biological functions: Toddler/Apela/ELABELA is a secreted peptide that signals via a GPCR to promote gastrulation movement during zebrafish embryogenesis. More recently, the Pauli lab discovered Bouncer, a GPI-anchored, short membrane protein that functions as the gate-keeper of the oocyte: Bouncer is not only essential for sperm entry into the egg, but also mediates species-specificity of fertilization. These findings have firmly established short proteins as an exciting new research area.
Read more about Andreas Pauli´s research
Host: Dörte Schlesinger, dorte.schlesinger@localhost
Necessary cookies are absolutely essential for the website to function properly. This category only includes cookies that ensures basic functionalities and security features of the website. These cookies do not store any personal information.
Any cookies that may not be particularly necessary for the website to function and is used specifically to collect user personal data via analytics, ads, other embedded contents are termed as non-necessary cookies. It is mandatory to procure user consent prior to running these cookies on your website.