Institute of Bioanalytical Chemistry, Humboldt University Berlin
Dr. Dietrich Volmer obtained his PhD in 1994 from the University of Hannover, Germany, followed by postdoctoral research at the National Center for Toxicological Research in Jefferson, AR, USA. He then held academic appointments in Halifax in Canada, in Cambridge (UK) and, until recently as Chair in Bioanalytical Chemistry at Saarland University in Saarbrücken, Germany. Since April 2018, he is Chair in Analytical Chemistry at Humboldt University in Berlin. Dietrich Volmer is also editor of Rapid Communications in Mass Spectrometry since 2003.
A plethora of contradictory research surrounds vitamin D and its influence on health and disease. This may partly result from analytical difficulties with regard to measuring vitamin D metabolites in serum. Indeed, variation exists between analytical techniques and assays used for the determination of serum 25-hydroxyvitamin D. Research studies into the effects of vitamin D on clinical endpoints rely heavily on the accurate assessment of vitamin D status. This has important implications, as findings from vitamin D-related studies to date may potentially have been influenced by the quantification techniques used. Likewise, healthcare professionals are increasingly incorporating vitamin D testing and supplementation regimens into their practice, and measurement errors may also be confounding the clinical decisions. This presentation highlights the most important analytical challenges and their impact on accuracy of measurement. It will also assess whether the universally praised “gold standard” technique mass spectrometry can measure up to its reputation in vitamin D testing.
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