Monday, November 2, 2020 zoom meeting
SciLifeLab Fellow, Uppsala University
Mikael E. Sellin has a PhD in Cell Biology from Umeå University and conducted Post-doctoral work in microbiology at the ETH Zürich, Switzerland. Since 2016, he runs an infection biology laboratory at Uppsala University and SciLifeLab.
Bacterial gut infections represent a globally prevalent cause of disease. Traditionally, the bacterium – host cell interactions that underlie disease development have been studied under simple experimental settings, using tumour-derived cell lines as a proxy for the gut tissue. The Sellin laboratory seeks to explain the mechanisms that drive invasive gut bacterial disease (e.g. elicited by Salmonella and Shigella bacteria) under more physiologically relevant conditions. We combine bacterial genetics and live imaging with methods to grow miniature replicas of the mammalian gut – so called intestinal organoids – outside of the body. In this seminar, I will illustrate how organoid technology may revolutionize studies of bacterial infection. I will use examples from our recent work to highlight how we can map, and visualize in real time, bacterial invasion of the intestinal epithelium. I will also describe how efficient removal of infected epithelial cells allows the host to counter the attack and avoid systemic bacterial spread.
Keywords: Enterobacteria, Infection, Epithelium, Enteroid, Inflammasome, Cell death, Bioimaging
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