The seminar will be held in Uppsala on Monday 1 April 2019, at 15:15 at BMC Uppsala
in Stockholm on Tuesday 2 April 2019, at 15:00 at Auditorium Air and Fire, SciLifeLab Campus Solna
Technical University Vienna, Biophysics Group, Institute of Applied Physics, Vienna, Austria
Prof. Gerhard Schütz studied physics at the Johannes Kepler University Linz, where he received his PhD (1997) and his habilitation (2004). From 2004 – 2011 he was Associate Professor at the Johannes Kepler University Linz. In 2011, he was appointed full professor at TU Wien. Gerhard Schütz has been working in the field of single molecule biophysics since the beginning, and recently included also superresolution microscopy in his portfolio.
Quantification is the heart of every scientific discipline, as it provides a solid basis to mathematical models, which are required for understanding complicated systems. Since a few ten years, researchers have started to model also cell biological processes mathematically, yielding predictions that are testable by experiments. In many cases, however, the outcome was rather disappointing: many models did not assume the correct molecular mechanism, thereby leading to increased confusion instead of clarifications. Part of the problem are limitations in current measurement technologies; ideally, we would like to directly observe and quantify molecular processes in the natural cellular context. In my talk I will showcase by a few examples, how we can determine molecular parameters like protein association, its kinetics, and its dependence on the cellular environment directly in the living cell using single molecule techniques. I will highlight parameters that have been largely overlooked, such as forces acting on biomolecules. Finally, I will also show some pitfalls that may occur on our way to quantitative results.
Host: Stefan Wennmalm
Necessary cookies are absolutely essential for the website to function properly. This category only includes cookies that ensures basic functionalities and security features of the website. These cookies do not store any personal information.
Any cookies that may not be particularly necessary for the website to function and is used specifically to collect user personal data via analytics, ads, other embedded contents are termed as non-necessary cookies. It is mandatory to procure user consent prior to running these cookies on your website.