This seminar is co-organized with the Lennart Philipson Memorial Lecture committee.
Read more about Malin and Lennart Philipson foundation or See a movie about Lennart Philipson
Karolinska Institutet, MTC, Sweden and A*STAR Singapore
David Lane is best known for his work on the p53 pathway. He did his undergraduate and PhD studies at University College London working in immunology and specifically auto-immunity. After Post Docs in London and Cold Spring Harbor he set us his own lab in London and later in Dundee and Singapore and now in Sweden. He wrote the CSH Antibody Manual with Ed Harlow, started the Nasdaq listed biotech company Cyclacel Pharmaceuticals and established the Experimental Therapeutics Center in Singapore. He has a passion for drug discovery, antibodies and protein protein interactions.
Small molecule drugs and large protein therapeutics are the mainstay of current pharmaceutical research. However, it is difficult to make these molecules disrupt protein protein interactions (PPI) inside the cell. One can try to make antibodies go inside cells or make “big” small molecules that can bind to the often rather “flat” molecular interfaces that describe many PPI’s. The study of PPI’s suggests an alternate approach, since many of them involve short helical peptides. Can these peptides be turned into drugs? Two clear challenges emerge. The peptides are normally unstable because they are cleaved by proteases, and they do not appear to go into cells effectively. Using extensive synthesis and a wide variety of biochemical and cell based assays we have been able to iteratively overcome these problems and develop families of highly promising molecules that are effective in vivo. Understanding cell uptake remains the most complex problem.
The Lennart Philipson memorial lecture committee
Göran Akusjärvi – Department of Medical Biochemistry and Microbiology (IMBIM)
Jyoti Chattopadhyay – Department of Cell and Molecular Biology (ICM)
Ulf Pettersson – Department of Immunology, Genetics and Pathology (IGP)
Anders Virtanen – Department of Cell and Molecular Biology (ICM)
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