Johns Hopkins University Biophysics & Biomedical Engineering, Howard Hughes Medical Institute, Baltimore, USA
Taekjip Ha is the Bloomberg Distinguished Professor of Biophysics and Biophysical Chemistry and a Howard Hughes Medical Institute Investigator at Johns Hopkins University. He is developing novel physical methods to tag and manipulate single molecules to evaluate their behavior and interactions. He uses fluorescence resonance energy transfer (FRET) and other biophysical techniques to study helicases and ribozymes, and how malfunctions occur in chromosome separation during meiosis.
DNA is an iconic molecule that forms a double helical structure, providing the basis for genetic inheritance, and its physical properties have been studied for decades. In this talk, I will present evidence, obtained through single molecule optomechanical measurements and high throughput sequencing methods, that sequence and methylation dependent physical properties of DNA such as bendability and self-association may be important for chromatin functions.
Host: Sebastian Deindl (firstname.lastname@example.org)
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