BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//SciLifeLab - ECPv6.15.18//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:SciLifeLab
X-ORIGINAL-URL:https://www.scilifelab.se
X-WR-CALDESC:Events for SciLifeLab
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:Europe/Stockholm
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20210328T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20211031T010000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20220327T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20221030T010000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20230326T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20231029T010000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20221107T151500
DTEND;TZID=Europe/Stockholm:20221107T161500
DTSTAMP:20260404T003713
CREATED:20221025T140529Z
LAST-MODIFIED:20221103T114505Z
UID:144816-1667834100-1667837700@www.scilifelab.se
SUMMARY:[The Svedberg] - Studying microRNA functions at the single-cell level
DESCRIPTION:MicroRNAs are gene regulatory molecules that play important roles in numerous biological processes including human health. The function of a given microRNA is defined by its selection of target transcripts\, yet current state-of-the-art experimental methods to identify microRNA targets are laborious and require millions of cells – hampering the entry of the microRNA field into the single-cell era. We have overcome these limitations by fusing the microRNA effector protein Argonaute2 to the RNA editing domain of ADAR2\, allowing for the first time the detection of microRNA targets transcriptome-wide in single cells. Our agoTRIBE method reports functional microRNA targets which are additionally supported by evolutionary sequence conservation. As a proof-of-principle\, we study microRNA interactions in single cells\, and find substantial differential targeting across the cell cycle. In addition to presenting this single-cell project\, I will talk about our recent efforts to sequence RNA fragments from ancient animal samples that are preserved in the Siberian permafrost. \n\n\n\nMarc Friedländer is an associate professor at Stockholm University\, Department of Molecular Biosciences. He graduated from his master’s thesis under the supervision of Anders Krogh in Copenhagen and his PhD in the group of Nikolaus Rajewsky in Berlin. He founded his own lab in Stockholm with funding from a SciLifeLab Fellowship and an ERC starting grant. His team is balanced between wet-lab and dry-lab biologists\, and they develop and apply experimental and computational methods to understand gene regulation – with particular emphasis on microRNAs. His lab has studied these molecules in the context of space exposure (a collaboration with NASA); in ancient animal samples preserved in permafrost; and in mammalian single cells. \n\n\n\nWebpage: www.friedlanderlab.org
URL:https://www.scilifelab.se/event/the-svedberg-marc-friedlander-assoc-prof/
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png
ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
END:VEVENT
END:VCALENDAR