BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//SciLifeLab - ECPv6.15.20//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:SciLifeLab
X-ORIGINAL-URL:https://www.scilifelab.se
X-WR-CALDESC:Events for SciLifeLab
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:Europe/Stockholm
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20240331T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20241027T010000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20250330T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20251026T010000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20260329T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20261025T010000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=Europe/Stockholm:20250422T151500
DTEND;TZID=Europe/Stockholm:20250422T161500
DTSTAMP:20260421T123959
CREATED:20250409T070149Z
LAST-MODIFIED:20250409T070826Z
UID:184820-1745334900-1745338500@www.scilifelab.se
SUMMARY:[The Svedberg seminar]-The origins and functional evolution of amniote sex chromosomes
DESCRIPTION:Henrik Kaessmann \n\n\n\nProfessor of Evolutionary Genomics at Heidelberg \, Germany \n\n\n\nBio\n\n\n\nDr. Henrik Kaessmann is Professor of Evolutionary Genomics at Heidelberg University. His research focuses on the molecular foundations of mammalian phenotypic evolution\, leveraging various comparative and functional genomics approaches. After earning his Ph.D. at the Max Planck Institute for Evolutionary Anthropology\, he conducted postdoctoral research at the University of Chicago as an EMBO Fellow. His interdisciplinary lab\, which he initially established in Lausanne (Switzerland)\, has pioneered large-scale studies of gene expression changes and their phenotypic implications across various biological dimensions\, including organs\, species\, developmental stages\, gene expression layers\, coding and noncoding gene types\, splicing isoforms\, and sexes. Prof. Kaessmann has published extensively in leading journals and has received numerous prestigious honors\, including three ERC grants\, EMBO membership\, the Friedrich Miescher Award\, and the Cloëtta Prize. Beyond his research\, he teaches and mentors at Heidelberg University and maintains active collaborations with clinical researchers and major scientific institutions worldwide.Collectively\, Henrik Kaessmann’s transformative work has profoundly advanced our understanding of the molecular foundations of mammalian phenotypic evolution and the driving forces of natural selection. The remarkable scope of his lab‘s major findings demonstrates how large-scale genomics approaches can yield fundamental biological insights and test key hypotheses. Notably\, his interdisciplinary research has had far-reaching impact beyond evolution and development\, as evidenced by extensive citations across diverse fields. His findings\, including the observation of functional divergence of many genes between humans and mice\, and unique gene expression (i.e.\, transcriptome\, epigenome\, translatome) datasets  spanning key organs and developmental stages in humans and various model and non-model species\, have become indispensable resources for biomedical research in general. To maximize their impact\, his team has created interactive public databases that ensure optimal usability for the scientific community. \n\n\n\n \n\n\n\nThe origins and functional evolution of amniote sex chromosomes\n\n\n\n In our lab\, we carry out large-scale studies of gene expression changes and their phenotypic implications across various biological dimensions (e.g.\, species\, organs\, developmental stages\, gene expression layers\, coding and noncoding gene types\, splicing isoforms\, and sexes). In this seminar\, I will focus on our endeavors to unravel the origins of the different amniote sex chromosome systems\, which emerged from ancestral sets of autosomes. We have\, for example\, unveiled the origins of the sex chromosomes of therian (i.e.\, placental and marsupial) and monotreme mammals\, and those of birds and lizards. We then scrutinized the evolutionary and functional consequences of sex chromosome differentiations (i.e.\, the degeneration of Y or W chromosomes in males or females\, respectively) and the associated selective forces. Overall\, our work has illuminated the evolution of the specific gene contents on the respective sex chromosomes\, the origins and consequences of male (meiotic) sex chromosome inactivation\, and the forces and mechanisms underlying the evolution of the various amniote dosage compensation mechanisms\, including the drivers underlying the emergence of the female X inactivation mechanism in therians. I will present published and unpublished highlights of our work \n\n\n\nHost: Leif Andersson leif.andersson@imbim.uu.se
URL:https://www.scilifelab.se/event/the-svedberg-seminar-henrik-kaessmann/
LOCATION:BMC Room C8:301\, Husargatan 3\, Uppsala\, Sweden
CATEGORIES:Event
ATTACH;FMTTYPE=image/png:https://www.scilifelab.se/wp-content/uploads/2022/02/Picture1-The-Svedberg.png
ORGANIZER;CN="The Svedberg Seminar Series":MAILTO:thesvedberg@scilifelab.uu.se
END:VEVENT
END:VCALENDAR